INTRODUCTION The commonest form of autoimmune hemolytic anemia is characterized by the presence of antibody of the IgG immunoglobulin class on the red cell (1). These antibodies characteristically react with red cell antigens at body temperature, and they fix complement relatively inefficiently since two antibody molecules in juxtaposition are required to initiate a complement sequence (2). The...

Proteins of the Bcl2 family play a key role in controlling the activation of caspases, the proteases that dismantle the cell in programmed cell death (Adams and Cory, 1998; Korsmeyer, 1999; Vaux and Korsmeyer, 1999). Bcl2-related proteins fall into two groups that generally either repress apoptosis (Bcl2, Bcl-xL [Bcl2lL], Bcl-w [Bcl2l2], A1 and Mcl1) or promote apoptosis (Bax, Bcl-xs [Bcl2ls], ...

Electronic health record-keeping systems in the Referent Tracking paradigm use globally unique identifiers to make explicit reference to all relevant particular entities, and structure data by referring to universals and relations defined in external, commonly-used ontologies. SNePS is a general-purpose Knowledge Representation, Reasoning and Acting system with a logical language interface. We ...

the binding of proportionately larger quantities of the third component of complement (C3) to these cells. The same amount of bound C3 was found on the membranes of normal and HEMPAS cells for a given degree of lysis. Hence, the marked increase in lysis of HEMPAS cells is due to the increased adsorption of antibody and/or increased binding of C4. PNH cells bound the same amount of C4 per bound ...

the binding of proportionately larger quantities of the third component of complement (C3) to these cells. The same amount of bound C3 was found on the membranes of normal and HEMPAS cells for a given degree of lysis. Hence, the marked increase in lysis of HEMPAS cells is due to the increased adsorption of antibody and/or increased binding of C4. PNH cells bound the same amount of C4 per bound ...

When several choice options are sampled one at a time in a sequence and a single choice of the best option is made at the end of the sequence, which location in the sequence is chosen most often? We report a large-scale experiment that assessed tasting preferences in choice sets of two, three, four, or five wines. We found a large primacy effect—the first wine had a large advantage in the endof...

Garnham, Malaria Parasites and Other Haemosporidia (Blackwell Scientific, Oxford, 1966)]. Sex ratios based on counts of 50 to 75 gametocytes were found to be representative. We calculated sex ratios from either 50,000 RBCs or 100 gametocytes, whichever was less. Sex ratios are given as proportion of males. 7. R. E. Sinden, G. A. Butcher, O. Billker, S. L. Fleck,. Adv. Parasitol. 38, 53 (1996). ...

People with schizophrenia have problems with social functioning, and it may be related to deficits in processing social information. This study investigated how people with schizophrenia process eye gaze, a form of self-referential social information, and whether it is related to paranoia symptoms in schizophrenia. Twenty-one participants with schizophrenia and 26 healthy controls were shown fa...

This paper describes a case study conducted within the domain of blood transfusion aiming at non-exhaustively extraction of candidate terms for an ontology of human blood. The process involved both the construction of a corpus and its automatic processing, and the retrieval of specialized terms. As our main result, we have obtained candidate medical terms to be used in a ontology of blood trans...

Ral GTPases have been implicated as critical drivers of cell growth and metastasis in numerous Ras-driven cancers. We previously reported stapled peptides, based on the effector RLIP76, that can disrupt signaling. Stapled peptides are short locked into their bioactive form using a synthetic brace. Here, an affinity maturation RLIP76 Ral-binding domain, we identified several sequence substitutio...