CL307-24, a complex of new antibiotics has been isolated from the fermentation broth of Saccharopolyspora aurantiaca sp. nov. The complex was purified by cation-exchange and hydrophobic interaction chromatographies. It was then resolved as one major and three minor components by silica gel chromatography and HPLC.

Saccharopolyspora rectivirgula is the main cause of farmer's lung disease. The development of recombinant antigens to standardize the serodiagnosis of the disease requires knowledge of the S. rectivirgula genome. We sequenced the genome of an environmental strain, S. rectivirgula DSM 43113. A total of 3,221 proteins were found to be encoded in a short 3.9-Mb genome.

objective: doxorubicin (dox) is an effective anticancer drug but its clinical application is limited because it induces apoptosis in cardiomyocytes and leads to permanent degenerative cardiomyopathy and heart failure possibly due to oxidative stress. recent studies showed that capparis spinosa (c. spinose)exhibits potent antioxidant activity. so, in this study, we explored the protective effect...

Capparis spinosa L. (C. spinosa) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. Here, we prepared the C. spinosa fruit ethanol extracts (CSEs) using different procedures and investigated the effects of CSE on the maturation of mouse bone marrow-derived dendritic cells (DCs) in the absence or presence of lipopolysaccharide (LPS). DC matura...

ETHNOPHARMACOLOGICAL RELEVANCE Magnolia officinalis Rehder and Wilson [Magnoliaceae] bark and Ziziphus spinosa (Buhge) Hu ex. Chen. [Fam. Rhamnaceae] seed have a history of use in traditional Asian medicine for mild anxiety, nervousness and sleep-related problems. AIM OF THE STUDY To identify pharmacological targets, extracts of Magnolia officinalis (ME), Ziziphus spinosa (ZE), and a propriet...

Reinhold Deml Lehrstuhl für Tierökologie II, Universität Bayreuth, D-95440 Bayreuth, Germany. E-mail: [email protected] Z. Naturforsch. 56c, 89-94 (2001); received September 12/October 18, 2000 Chemical Defense, Saturniidae, Secondary Compounds Scolus secretions and hemolymph of caterpillars of Satumia pyri fed with two different foodplants (Crataegus monogyna, Prunus spinosa) were ...

Plants have been the source of several effective drugs for the treatment of cancer and over 60% of anticancer drugs originate from natural sources. Therefore, extracts of the rhizome of Smilax spinosa, an ethnomedicinal plant from Guatemala which is used for the treatment of inflammatory conditions, were investigated regarding their anti-neoplastic activities. By using several solvents the meth...

pycnocycla spinosa decne. ex boiss. var. spinosa (fam. umbelliferae) is an essential oil-containing wild plant growing in central part of iran. hydroalcoholic extract of pycnocycla spinosa has antispasmodic and antidiarrheal activity. the aim of this study was to further investigate antidiarrheal and small intestinal transit effect of p. spinosa extract for a comparison with loperamide and dicy...