Dr. Benacerraf describes his experience in training immunologists for a period of over 30 years. He then analyzes the circumstances in which selected discoveries were made in his laboratory and the events and reasoning that led to these findings. The following topics are discussed: The phagocytic activity of the reticulo-endothelial system. The pathogenesis of immune complex diseases. The impac...

Emotional expressions have endured as a topic of profound scientific interest for over a century, in part due to Darwin’s classic volume, The Expression of Emotions in Man and Animals. Since its publication, there has been a strong, spirited debate over the origin, nature, and function of emotional expressions. In this article, I consider two basic questions: What did Darwin really write about ...

In a series of recent papers, John MacFarlane (2003, 2005a, 2005b) has formulated a version of truth-relativism, and argued for its application in some cases—future contingents, knowledge attributions and epistemic modals among them. Mark Richard (2004) also defends a version of relativism, which he applies to vagueness-inducing features of the semantics of gradable adjectives; Richard thinks t...

16 guitar intro w/ rhythm and lead guitars Bm /Gb /D#m /Gb(nonbar chords) Verse 1 Bm Gb I believe you're the One, I believe ya' D#m Gb Your hand was there to save me when my ship was goin' down Bm Gb You were there to dust me off and recieve me D#m Gb I'm not the same I bless your Name, I'm so glad that I'm found Bm Gb I hear your Word; I feel your love Lord, I need ya D#m Gb No man or no woman...

Practitioners and investigators often view clinical trials from very different perspectives-the former in terms of individuals and the latter in terms of groups. The following whimsical dialogue highlights the philosophical foundations of these contrasting perspectives and illustrates their potential impact on patient care and public policy. The title alludes to a piece by Lewis Carroll regardi...