BACKGROUND Dose-intensive chemotherapy with hematopoietic stem cell transplantation has been evaluated as a salvage treatment for recurrent ovarian cancer, but its benefit has not yet been demonstrated. In a previous phase I trial, we reported the feasibility of administering topotecan as a salvage regimen. METHODS Twenty-one patients were treated with escalating doses of topotecan associated...

Ocular Oncology Service, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India Email: [email protected] Abstract : Retinoblastoma is the most common malignant intraocular tumor of childhood, with an incidence of 1 in 16,000 to 18,000 live births. The most common symptoms of retinoblastoma are leukocoria and strabismus. The diagnosis of retinoblastoma is delayed in the developing countr...

Non-Hodgkin Lymphoma (NHL) B-Cell aggressive subtype (except mantle cell) Myeloablative autologous, myeloablative allogeneic or reduced-intensity conditioning (RIC) allogeneic HSCT with curative intent may be considered medically necessary:  As salvage for patients not in complete remission (CR) after first line chemotherapy induction;  To achieve or consolidate a CR in chemotherapy sensitive...

We present the case of a patient with acute myelomonocytic leukemia with trisomy 8 and novel translocation t(5;13). In addition to acute leukemia she had debilitating left shoulder arthritis due to granulocytic sarcoma formation in the joint space. Her shoulder pain did not improve during induction chemotherapy but she experienced rapid relief of symptoms with use of local radiation. Her leukem...

In the last two decades treatment for head and neck cancers has evolved with multiple modality treatments, including radiation and chemotherapy in an effort to enhance local and regional disease control, reduce distant metastasis, preserve anatomic structures ,and improve overall survival and quality of life (QOL). Surgery is first choice for early cancers and for cancers that do not respond to...

•Vulvar yolk sac tumor (YST) is an exceptionally rare and aggressive extra-gonadal germ cell tumor, previously only described in 15 cases in the literature.•We present a unique case of vulvar YST diagnosed during pregnancy, treated with systemic chemotherapy, who subsequently recurred during a second pregnancy.•Despite salvage chemotherapy and autologous stem cell transplantation at recurrence,...

Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, there has been little improvement in survival rates for patients with metastatic or recurrent ES. Herein we review the different current therapeutic approaches...

Renal lymphoma is an uncommon renal tumor in children. Unlike renal lymphomas presenting as bilateral disease and renal failure, we report a boy who presented with unilateral renal involvement. After initial nephrectomy, he achieved remission with multiagent chemotherapy but relapsed systemically within 3 months. He was initiated on salvage chemotherapy with autologous bone marrow transplant. E...

BACKGROUND The presence of a pathological fracture due to osteosarcoma (OS) has been considered a high risk factor for dissemination and an indication for immediate amputation. With current neoadjuvant chemotherapy regimens there is a trend towards limb salvage procedures in selected cases. The aim of this study is to assess the outcome of patients treated with amputation versus patients treate...

Salvage chemotherapy for relapsed/refractory FLT3-ITD-mutant acute myeloid leukemia (AML) is associated with a low complete remission (CR) rate (20–26%), despite the sequential use of a FLT3 inhibitor. FLT3 ligand rises precipitously after chemotherapy administration in advanced AML and is thought to have a detrimental effect on the activity of FLT3 inhibitors. Most studies involving FLT3 inhib...