Intraembryonic hematopoiesis occurs at two different sites, the floor of the aorta and subaortic patches (SAPs) of the para-aortic splanchnopleura (P-Sp)/aorta-gonad-mesonephros (AGM) region. Notch1 and RBP-jkappa are critical for the specification of hematopoietic stem cells (HSCs) in Notch signal-receiving cells. However, the mechanism by which Notch signaling is triggered from the Notch sign...

BACKGROUND Mortality predictive indexes have not been applied to patients in general wards out of the ICU. METHODS Retrolective study aimed to evaluate the value of mortality prediction indexes in a cohort of 944 non-critical patients. Three indexes were evaluated according to their calibration and discriminative power: the Mortality Probability Model II (MPMII), the Simplified Acute Physiolo...

The aim of the research was to show our diagnostic and therapeutic experience with antiphospholipid syndrome (APS) in pregnant women. 36 pregnant women suspect on APS were included in the study: 32 with primary antiphospholipd syndrome (PAPS) and 4 with secondary antiphospholipid syndrome (SAPS). All pregnant women received low-molecular-weight-heparin (LMWH) and low dose aspirin (LDA) therapy....

Sympathoadrenergic progenitor cells (SAPs) of the peripheral nervous system (PNS) are important for normal development of the sympathetic PNS and for the genesis of neuroblastoma, the most common and often lethal extracranial solid tumor in childhood. However, it remains difficult to isolate sufficient numbers of SAPs for investigations. We therefore set out to improve generation of SAPs by usi...

In the central auditory system, cartwheel cells (CWCs) are a group of interneurons in the dorsal cochlear nucleus (DCN). While other DCN neurons respond to stimuli with a simple discharge pattern of single action potentials (SAPs), CWCs respond with complex action potentials (CAPs), consisting of SAPs superimposed on a slow depolarization. The CAPs in CWCs may participate in various auditory or...

Abstract The Almost Perfect Scale-Revised (APS-R) and its short form (SAPS) are among the most-established multidimensional perfectionism measures. Yet, investigations into APS-R/SAPS nomological networks have mainly been limited to level of broader personality traits. This reliance on trait-level associations hampers conceptual understanding traits by masking more complex relations with specif...

Previous meta-analyses have shown a superiority of acupuncture over artificial tear for treating typical dry eye syndrome (DES). However, given that the protocols were quite diverse in randomized controlled trials (RCTs) included meta-analyses, it is necessary to establish guidelines. Thus, optimal protocol involved improvements tear-film breakup time (BUT) or Schirmer test (STT) was examined b...

Objectives The aim of this study was to compare the discriminatory power of two prognostic scores, SAPS 3 and APACHE II, in surgical patients. Methods Retrospectively collected data from all surgical patients admitted to a Brazilian hospital ICU between January 2011 and December 2013 were analyzed. The standardized mortality ratio (SMR) was computed for mortality prediction. The predictive abil...

BACKGROUND The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients. METHODS A total of 1440 patients admitted to 22 ICUs (medical, 14; surgical, six; mult...