Cutaneous spindle cell malignancies such as sarcomatoid squamous cell carcinoma (SCC), leiomyosarcoma, desmoplastic melanoma (DM) and atypical fibroxanthoma (AFX) may be morphologically indistinguishable, yet accurate diagnosis is important for appropriate clinical management. The distinction among these entities relies on immunohistochemical evaluation for epidermal, muscle or melanocytic diff...

Background Sarcomatoid bladder cancer is a rare and aggressive variant of urothelial carcinoma. Methods A retrospective review of our experience in managing patients with sarcomatoid bladder cancer (SRBC) between 1997 and 2011 was performed to better define the behavior and outcomes of this disease. Results The median age of the patients was 63 years. All patients presented with high grade ...

Sarcomatoid change in renal cell carcinoma is the result of the dedifferentiation of the "parent" tumor into a high-grade malignancy characterized by sarcoma-like features and associated with an accelerated clinical course and poorer prognosis. Any of the renal cell carcinoma subtypes can undergo sarcomatoid dedifferentiation, with the chromophobe variant being the most prone. The present repor...

Sarcomatoid carcinoma is a rare, aggressive tumor, with a special predilection for the upper bronchodigestive tract and oral cavity (1-3), but it may occur in other locations such as the uterus and breast. This tumor has a mixture of carcinoma and sarcoma containing differentiated mesenchymal elements (1-3). Orbital apex syndrome is a rare complex characterized by proptosis and paralysis of ext...

Sarcomatoid carcinoma of the prostate is among the rarest malignant neoplasm types and has been well known for its aggressive clinical course. Patient was admitted with the symptoms of lower urinary tract. Transurethral resection of prostate (TUR-P) was carried out. Revealing Gleason 5 + 3 = 8 prostate adenocarcinoma in TUR-P material. Thereby, a Radical Prostatectomy procedure was planned. In ...

Because sarcomas of the anterior lower neck region occur so infrequently, they are not usually considered in the differential diagnosis of Riedel's thyroiditis. Riedel's thyroiditis itself may be confused on clinical grounds alone with malignant neoplasms because of its invasive features. Sarcomatoid carcinoma is the main entity to be discarded in this regard. This is accomplished through histo...

 With glandular differentiation/adenocarcinoma, if pure  With squamous differentiation/squamous carcinoma, if pure verrucous carcinoma  With small cell differentiation  With trophoblastic differentiation  Clear cell  Nested variant microcystic/tubular variant large cell nested variant  With inverted growth pattern  Cystic variant/resembling cystitis cystica  Micropapillary variant  Ly...