Sickle cell anemia (SCA) and its complications result in significant morbidity and mortality, posing a significant public health challenge worldwide. SCA and its societal costs disproportionally affect Africa. A strong geographical link between the highest HbS allele frequencies and high malaria endemicity was observed at the global scale, but this observation is influenced primarily by the rel...

Snow is an important component of the water cycle, and its estimation in hydrological models is of great significance concerning the simulation and forecasting of flood events due to snow-melt. The assimilation of Snow Cover Area (SCA) in physical distributed hydrological models is a possible source of improvement of snowmelt-related floods. In this study, the assimilation in the LISFLOOD model...

Nuclear magnetic resonance (NMR) relaxometry tests, carried out on partially saturated porous media, convey information on the distribution of fluids within the pore space. Proper interpretation of this information requires a means to isolate the effects of pore structure (pore and throat shape and size distributions, spatial correlations, etc.) wettability and saturation history. A pore networ...

Accurate estimation of capillary pressure and relative permeability curves are very important for evaluating hydrocarbon recovery processes. Also, resistivity index data are important in evaluating fluid distributions in reservoirs during these processes. All these parameters are path dependent i.e. different in drainage and imbibition processes, commonly known as hysteresis, which makes them c...

OBJECTIVE Differential expression of several genes between ACTH-secreting pituitary tumors causing Cushing' disease (CD), silent corticotroph adenoma (SCA), and non-functioning pituitary tumors (NFT) was investigated. DESIGN AND METHODS We used tissue specimens from 35 pituitary tumors (12 CD, 8 SCA, and 15 NFT). Steady-state mRNA levels of the genes related to proopiomelanocortin (POMC) tran...

BACKGROUND The hepatitis C Virus (HCV) has become an important cause of chronic liver disease and liver cancer worldwide. Blood transfusion is one of the important modes of transmission. There is need to study the prevalence among those at risk such as sickle cell anaemia (SCA) patients. Such information will broaden knowledge of the problem among SCA patients transfused with blood in this part...

BACKGROUND US high schools are increasingly adopting automated external defibrillators (AEDs) for use in campus settings. We analyzed the effectiveness of emergency response planning for sudden cardiac arrest (SCA) in a large cohort of US high schools that had onsite AED programs. METHODS AND RESULTS A cohort of US high schools with at least 1 onsite AED was identified from the National Regis...

BACKGROUND Sports-associated sudden cardiac arrests (SCAs) occur mostly during middle age. We sought to determine the burden, characteristics, and outcomes of SCA during sports among middle-aged residents of a large US community. METHODS AND RESULTS Patients with SCA who were 35 to 65 years of age were identified in a large, prospective, population-based study (2002-2013), with systematic and...

Physiologic contributors to reduced exercise capacity in individuals with sickle cell anemia (SCA) are not well understood. The objective of this study was to characterize the cardiopulmonary response to maximal cardiopulmonary exercise testing (CPET) and determine factors associated with reduced exercise capacity among children and young adults with SCA. A cross-sectional cohort of 60 children...