OBJECTIVES To determine the underlying causes of death in a large population based register series of patients with multiple sclerosis. METHODS The Danish Multiple Sclerosis Registry, which contains virtually all diagnosed cases of multiple sclerosis in Denmark who were alive in 1949 plus cases with onset of multiple sclerosis in the period 1949-93, who have been diagnosed and notified by 1 J...

BACKGROUND Epidemiologic similarities between Hodgkin lymphoma in young adults (i.e., between 15 and 44 years old) and multiple sclerosis have led to the suggestion that these diseases may have related etiologies. Previous investigations have not supported this hypothesis, but the negative results could have been caused by methodologic problems. We therefore assessed the risk of developing Hodg...


 Treatment with riluzole may provide clinical benefits for patients amyotrophic lateral sclerosis, including longer survival time, reduced risk of disease progression, and minor reversible adverse events, compared to no treatment or a placebo.
 We did not find any studies meeting our selection criteria on the effectiveness sclerosis alternative pharmacological therapies.
 Riluzo...

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of central nervous system (CNS). MS diagnosis and monitoring are mostly based on Magnetic Resonance Imaging (MRI). This study aims to compare a double inversion recovery MRI sequence with fluid-attenuated in Sclerosis brain. A was conducted 75 patients whose aged between 10 70 years who were having brain

Tuberous sclerosis is not as rare as once thought and has high psychiatric comorbidities. However, bipolar or psychotic features associated with tuberous sclerosis have been rarely reported. This report first presents a tuberous sclerosis patient, resembling a schizoaffective disorder of bipolar type. A patient with known tuberous sclerosis displayed mood fluctuation and psychotic features. Her...

purpose: to report the clinical, paraclinical and histopathologic features of eyelid mass lesions in a patient with tuberous sclerosis. case report: a 14 year old boy with a slowly progressive right upper lid mass and history of seizures, mental retardation and multiple skin lesions on the face and body was referred to labbafinejad medical center. cortical tubers and subepandimal nodules were r...

PURPOSE To determine whether magnetization transfer contrast can differentiate acute from chronic lesions in multiple sclerosis. METHODS Thirteen patients with multiple sclerosis and eight healthy patients were studied with MR using a 0.1-T system. Relatively T2-weighted spin-echo images were obtained without and with magnetization transfer contrast. The magnetization transfer effect of multi...

OBJECTIVE The aim of this study was to investigate unidimensionality and differential item functioning of the SF-36 physical functioning scale (PF10) in patients with various neurological disorders. PATIENTS PATIENTS post-stroke (n = 198), with multiple sclerosis (n = 151) and amyotrophic lateral sclerosis (n = 193) participated. METHODS Unidimensionality of the PF10 within the patient grou...

BACKGROUND Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive. OBJECTIVE To investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cas...