PURPOSE Some studies report a role of leukotrienes in the pathogenesis of atopic dermatitis and suggest a rationale for the use of leukotriene receptor antagonist (LTRA) in the treatment of atopic dermatitis. This study aimed to evaluate the treatment effectiveness of montelukast in children with atopic dermatitis. METHODS Fifty-four children between the ages of 2 and 6 years with moderate to...

BACKGROUND The skin of atopic dermatitis (AD) patients has a high susceptibility to Staphylococcus aureus colonization, and the toxins produced by S. aureus may aggravate AD by acting as superantigens. OBJECTIVE The purpose of this study was to evaluate the relationship of the skin barrier function, colonization of S. aureus, and the clinical severity of AD. We also examined the predominant t...

BACKGROUND Atopic dermatitis, a chronic recurrent disease, is frequently encountered in clinical practice. In the last 30 years, the prevalence of atopic dermatitis has rapidly increased due to industrialization. Therefore, there have been attempts in recent years to find new ways of treating and preventing atopic dermatitis. OBJECTIVE In this double-blind, randomized, placebo-controlled stud...

background atopic dermatitis (ad) is a chronic inflammatory skin disease. phototherapy is considered as an effective treatment modality in severe cases. objectives in this study, we proposed to evaluate the efficacy of bath puva (psoralen plus ultraviolet a) in the treatment of severe and atopic dermatitis. patients and methods twenty-eight patients with severe atopic dermatitis were included i...

DUPISTAD (NCT04033367) evaluated the impact of dupilumab on sleep. Adults with moderate-to-severe AD (EASI ≥12, Pruritus numerical rating scale (NRS) ≥ 3 and sleep NRS ≥5) were randomized 2:1 to 300mg every 2 weeks (q2w) or placebo for 12 (W12); both groups permitted concomitant topical corticosteroids. The primary efficacy endpoint was quality percentage change from baseline W12, assessed by 1...

Background and aim: Atopic dermatitis (AD) is a chronic relapsing skin disease that commonly begins during infancy and early childhood. Research studies refers to a relationship between exacerbation of atopic dermatitis and exposure to house dust mite (HDM), but the role of HDM in the pathogenesis of AD is controversial. The objecitve of this study was to assess the correlation of density...