BACKGROUND Flavonoid-rich extracts from the mature roots of Scutellaria baicalensis have been shown to exhibit antiproliferative effects on various cancer cell lines. We assessed the ability of an ethanolic extract of S. baicalensis root to inhibit the proliferation of malignant glioma cells. METHODS Cell lines derived from primary and recurrent brain tumors from the same patient and cells se...

We determined the in vitro antioxidant activity of methanolic extracts from the shoots and roots of Scutellaria species (S. altissima and S. alpina) against the action of strong oxidants: hydrogen peroxide (H2O2) and H2O2+Fe(2+) (donor of hydroxyl radicals) on plasma proteins and lipids. Lipid peroxidation in human plasma was measured by the level of thiobarbituric acid reactive species (TBARS)...

Shi Yu, 2, 3 Peng Xu, 2 Xiaodong He, 2 Min Liu, 2 Jin Wang, 2 and Mingsheng Zhan 2, ∗ State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences Wuhan National Laboratory for Optoelectronics, Wuhan 430071, China Center for Cold Atom Physics, Chinese Academy of Sciences, Wuhan 430071, China Graduate Univers...

Two new norditerpenoid alkaloids, named scutebarbatines M-N (1 and 2), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were established on the basis of detailed spectral analyses. In vitro, two new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma and HT29 colorectal carcinom...

Four undescribed pyranone derivatives, named ascomycopyrones A–D (1–4), as well one known analogue simplicilopyrone (5) (this is the first study to report absolute configuration), were isolated from endophytic fungus Ascomycota sp. FAE17 derived flowers of Scutellaria formosa. The structures these pyranones identified by comprehensive spectroscopic and MS analyses, configurations determined the...

Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition from Morus alba, Scutellaria baicalensis,...

OBJECTIVE Scutellaria luteo-caerulea Bornm. & Snit. is one of the species of genus Scutellaria, within the family of the Lamiaceae, that is used for immune system stimulation and antibacterial effects in traditional medicine in Iran. The aims of this study were to analyze essential oils and mineral element contents of leaves of S. luteo-caerulea in flowering stage of development. MATERIALS AN...

Scutellariae radix (SR), also known as Huangqin, is the dried root of Scutellaria baicalensis Georgi (Lamiaceae). It is listed in the Chinese Pharmacopoeia and is one of the most widely used Chinese herbal medicines against bacterial infection of the respiratory and the gastrointestinal tracts. The main components of SR (and of all Scutellaria species) are baicalein, baicalin, and wogonin. Rhin...