Heterologous channel expression can be used to control activity in select neuronal populations, thus expanding the tools available to modern neuroscience. However, the secondary effects of exogenous channel expression are often left unexplored. We expressed two transient receptor potential (TRP) channel family members, TRPV1 and TRPM8, in cultured hippocampal neurons. We compared functional exp...

introduction: in the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. methods: in this study, ampa and nmda receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. resu...

The existence of secondary flows in the pressure-driven flow of a concentrated suspension of noncolloidal particles through a conduit of square cross section under creeping flow conditions is confirmed experimentally. This Letter lends support to the idea that secondary currents, rather than shear-induced migration, may actually be the dominant mechanism that determines particle distribution in...

the goal of this study was to determine the effects of the l-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fkv1.4δn), an n-terminal-deleted mutant of the ferret kv1.4 potassium channel. measurements were made using a two electrode voltage clamp technique with channels expressed stably in xenopus oocytes. the fkv1.4δn currents displayed...

background: ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. the mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. we aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...

in this paper, the large amount of sedimentation and the resultant shoreline advancements at the breakwaters of beris fishery port are studied. a series of numerical modeling of waves, sediment transport, and shoreline changes were conducted to predict the complicated equilibrium shoreline. the outputs show that the nearshore directions of wave components are not perpendicular to the coast whic...

The paper presents the structure of sensor for converting multi-phase primary currents into secondary voltages reactive power supply networks, algorithm modeling processes in that sends a signal to current monitoring and control devices provides highly formalized graph model based on an analytical expression, static characteristics errors studied basis its analytic expression.

In this study, the full Launder, Reece and Rodi pressure-strain model, nonlinear boundary damping functions were incorporated in OpenFOAM® to simulate turbulence-driven secondary currents supercritical narrow channel flows, such as sediment bypass tunnels. Five simulations performed under uniform flow conditions covering Froude numbers from 1.69 2.56 aspect ratios (channel width depth) ar 0.9 1...

We investigate the phase structure of pure compact U(1) lattice gauge theory in 4 dimensions with the Wilson action supplemented by a monopole term. To overcome the suppression of transitions between the phases in the simulations we make the monopole coupling a dynamical variable. We determine the phase diagram and find that the strength of the first order transition decreases with increasing w...