RIMARY immune deficiencies are genetic diseases caused by more than 200 single mutations. Each one of these mutations may/will affect the function of a cell activation pathway, a single cell population or a defined subset in innate or adaptive immunity.[1,2] Patients with secondary immunodeficiencies are a heterogenous group[3], comprising different disease entities: patients with HIV, patients...

Recent evidence suggests a much higher prevalence of human immunodeficiency virus type 1 (HIV-1) recombinants than previously anticipated. These recombinants arise from secondary HIV infections in individuals already infected with the virus. It remains unclear why some individuals acquire secondary HIV-1 infections and others do not. To address this question, a study was undertaken of a small c...

common variable immunodeficiency (cvid) is an antibody deficiency syndrome that often co-occurs in families with selective iga deficiency (igad). this study was designed to investigate the frequency of dr and dq loci of hla class ii region in common variable immunodeficiency (cvid) patients. fifteen iranian patients with cvid or igad (mean age 14.6±5.4, range 4-25 years; 9 male and 6 female) an...

glanzmann’s thrombasthenia (gt) is an autosomal recessive inherited platelet function defect characterized by normal platelet count, prolonged bleeding time and abnormal clot retraction. this disease typically presents in infancy or early childhood and has proven to have very good prognosis. in this case study, a 22‑year‑old gt patient who also developed human immunodeficiency virus (hiv) infec...

Objective: The prevalence of syphilis differs considerably between different populations and individual level risk factors such as number of sex partners seem unable to completely explain these differences. The effect of network level factors, such as the prevalence of partner concurrency, on syphilis prevalence has not hitherto been investigated. Study design: Linear regression was performed t...

OBJECTIVES This study was conducted to define factors associated with the epidemic spread, elimination, and reintroduction of primary and secondary syphilis in King County, Washington, from 1987 through 1998. METHODS Reports of primary and secondary syphilis in King County from 1987 through 1998 were reviewed retrospectively. RESULTS During the epidemic spread of syphilis, only 15.8% of cas...

OBJECTIVES The online universal Climate Schools intervention has been found to be effective in reducing the use of alcohol and cannabis among Australian adolescents. The aim of the current study was to examine the feasibility of implementing this prevention programme in the UK. DESIGN A pilot study examining the feasibility of the Climate Schools programme in the UK was conducted with teacher...

Introduction. Young people are at the centre of the global HIV/AIDS epidemic. This study therefore aimed to evaluate the effectiveness of peer education in improving HIV knowledge, attitude, and preventive practices among in-school adolescents in Osun State, Nigeria. Methods. This was an intervention study that was carried out among in-school adolescents attending mixed secondary schools in Osu...