The pars distalis of the tortoise, Geoclemis reevesii, was studied immunocytochemically with regards to its fine structure and distribution of different cell types. The pars distalis consists of cephalic and caudal lobes and a zona tuberalis, each with distinct cellular components. The cephalic lobe contains ACTH cells and prolactin (PRL) cells, while the caudal lobe consists of STH (GH) cells,...

IMR-32 human neuroblastoma cells are unable to release [3H]dopamine in response to secretagogues. However, they express a normal complement of membrane receptors and ion channels which are efficiently coupled to second messenger production. In the present study we took advantage of the ability of this cell line to differentiate in vitro in the presence of either dibutyrryl-cAMP or 5-bromodeoxyu...

The present study has disclosed for the first time the distribution of cytokeratin (CK) and  smooth muscle actin (SMA) in the accessory genital glands of camel. In prostate, CK was localized in the cytoplasm of columnar cells of secretory acini and in the scanty cytoplasm of basal cells. Conversely, no expression was seen in the capsule, fibromuscular septa, and blood vessels. In the ampulla ...

Exocytosis of secretory granules by adrenal chromaffin cells is blocked by the tetanus toxin light chain in a zinc specific manner. Here we show that cellular synaptobrevin is almost completely degraded by the tetanus toxin light chain within 15 min. We used highly purified adrenal secretory granules to show that synaptobrevin, which can be cleaved by the tetanus toxin light chain, is localized...

Electron microscope observations on eccrine sweat glands have been carried out by many workers, namely on human eccrine swear glands by HIBBS (1958), IIJIMA (1959), CHRALES (1960), KUROSUMI et al. (1960), and MUNGER (1961) and on those of animals by KITAMURA (1958), MUNGER et al. (1961), ELLIS et al. (1961), MATSUZAWA et al. (1963), KUROSUMI et al. (1964) and TERZAKIS (1964). Already by means o...

IMR-32 human neuroblastoma cells are unable to release [3H]dopamine in response to secretagogues. However, they express a normal complement of membrane receptors and ion channels which are efficiently coupled to second messenger production. In the present study we took advantage of the ability of this cell line to differentiate in vitro in the presence of either dibutyrryl-cAMP or 5-bromodeoxyu...

Ultrastructural and immunohistochemical studies of the small intestine are described in a Japanese patient with alpha heavy chain disease who had a history of colonic ulcers. Endoscopic examinations revealed multiple gastric erosion, duodenal ulcer, and a thickened, cobblestone-like pattern composed of small nodules in the duodenum and jejunum, which was similar in appearance to Crohn's disease...

Morphometric evidence derived from studies of mast cells, pancreatic acinar cells and other cell types supports a model in which the post-Golgi processes that generate mature secretory granules can be resolved into three steps: (1) fusion of small, Golgi-derived progranules to produce immature secretory granules which have a highly constrained volume; (2) transformation of such immature granule...

endoplasmic reticulum has a critical role in the synthesis and folding of secretory and membrane proteins. high accumulation of proteins in er activates the unfolded protein response and glucose regulated protein 78 or gpr78 plays an essential role in this pathway.  unfolded protein response is activated in cancerous cells due to their adverse condition to survive and it has been shown that grp...