IBRAHIM DUQUM: A Comparative study on the effect of Integrin subunits Beta one and Beta 3 on Osteoblast Implant interactions. Background: Integrin transmembrane receptors has emerged as central regulators of cell biomaterial interactions. Aim: to explore the effects of integrin β1 and β3 receptors on osteoblast implant surface interactions in vitro. Materials and methods: specific monoclonal an...

Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbances of regulatory and effector CD4 + T cells, which were regulated interleukin (IL)-2 1,2 . Objectives The aim this study was to systematically evaluate the efficacy safety low-dose IL-2 therapy in SLE treatment. Methods Systematic searches PubMed, EMBASE, Web Science, Cochrane Library Medline, CNKI...

Shrinking lung syndrome (SLS) is a rare and less known complication mainly associated with systemic lupus erythematosus (SLE). In this study, we analyze the clinical features, investigation findings, approaches to management, and outcome in a case series of 9 adult patients with SLE and SLS diagnosed during a 35-year period in 3 referral tertiary care hospitals in Spain. Additionally, we review...

INTRODUCTION The aim of this study was to evaluate the proportion of patients with Systemic Lupus Erythematosus (SLE) who did not met the WHO recommendations for physical activity and to evaluate the amount of time spent in sedentary behavior. METHODS SLE patients were consecutively enrolled in a cross sectional study. The type and the time spent in physical activity and sedentary behavior we...

OBJECTIVES Cognitive dysfunction has been reported in 20-80% of SLE patients. Converging evidence has indicated the importance of vitamin D as a neuroimmunomodulator for cognitive function. In this study, we evaluated the relationship between vitamin D and cognitive dysfunction. METHODS Consecutive age- and gender-matched SLE patients and healthy controls (HCs) were administered Automated Neu...

OBJECTIVE Current disease activity measures for systemic lupus erythematosus (SLE) are difficult to score or interpret and problematic for use in clinical practice. Lupus Foundation of America (LFA)-Rapid Evaluation of Activity in Lupus (REAL) is a pilot application composed of anchored visual analogue scores (0-100 mm each) for each organ affected by lupus. This study evaluated the use of LFA-...

Abstract The assessment of the seismic behaviour historic residential buildings and estimation their possible losses in event an earthquake, is a must for defining strategic mitigation plans to prevent irreplaceable heritage losses. In this study integrated performance based probabilistic risk methodology developed. An archival field survey allow identify architectural construction characterist...

OBJECTIVE The aim of this study was to develop an SLE disease model that simulates long-term outcomes of SLE to estimate the long-term effectiveness and cost-effectiveness of SLE treatments. METHODS Longitudinal data from 1354 patients from the Hopkins Lupus Cohort were included in the analysis. Statistical models were created to estimate disease activity [Safety of Estrogen in Lupus Erythema...