Introduction: Alzheimer’s disease is a progressive neurodegenerative disorder, characterized by impairment of memory and changes in behavior and personality. Recent evidence suggests that mitochondrial channels play important roles in memory disorders. Accordingly, the biophysical properties of a single potassium channel were investigated in the brain mitochondrial inner membrane of rat with...

1. Sodium and potassium efflux and influx rates were studied in normal human leucocytes in an artificial extracellular fluid using radioactive isotopes. 2. The rate constant for sodium efflux was 4-2 h-l corresponding to a sodium efflux rate of 487 mmol kg cell dry weight-’ h-l. Approximately three-quarters of this flux was ouabain sensitive. 3. Potassium influx was 346 mmol kg cell dry weight-...