Electrophysiological recordings with electrodes, or more generally, with arrays of multielectrodes, are key for recording neural activity data from the central nervous system. This technique delivers high temporal and spatial resolution, as well as enables neuron stimulation by current injection. The neuronal activity encoded by action potentials (simply called ”spikes”) of individual neurons, ...

In recent years, arrays of extracellular electrodes have been developed and manufactured to record simultaneously from hundreds of electrodes packed with a high density. These recordings should allow neuroscientists to reconstruct the individual activity of the neurons spiking in the vicinity of these electrodes, with the help of signal processing algorithms. Algorithms need to solve a source s...

The early endosomes constitute a major sorting platform in eukaryotic cells. They receive material through fusion with endocytotic vesicles or with trafficking vesicles from the Golgi complex and later sort it into budding vesicles. While endosomal fusion is well understood, sorting is less characterized; the 2 processes are generally thought to be effected by different, unrelated machineries. ...

Hydrodynamic microfluidic platforms have been proven to be useful and versatile for precisely sorting particles/cells based on their physicochemical properties. In this study, we demonstrate that a simple lattice-shaped microfluidic pattern can work as a virtual sieve for size-dependent continuous particle sorting. The lattice is composed of two types of microchannels ("main channels" and "sepa...

In this paper, we look at the complexity of designing algorithms without any bank conflicts in the shared memory of Graphical Processing Units (GPUs). Given input of size n, w processors and w memory banks, we study three fundamental problems: sorting, permuting and w-way partitioning (defined as sorting an input containing exactly n/w copies of every integer in [w]). We solve sorting in optima...

Epithelial cell polarity may be regulated by protein sorting in the Golgi and delivery to different membrane domains, a view from the inside looking out. But from the outside looking in, cell adhesion may be required first to establish sites for delivery, retention, and separation of membrane proteins, and delivery of presorted proteins from the Golgi subsequently reinforces and maintains diffe...

Cancer stem cells (CSCs) appear to be an essential target for cancer therapies, in particular, brain tumors such as Glioblastoma. Nevertheless, their isolation is made difficult by low content culture or (<5% of the tumor mass) and essentially based on use fluorescent magnetic labeling techniques, increasing risk differentiation induction. The label-free separation methods sedimentation field-f...