Ovarian borderline serous tumors are uncommon. Combination of borderline serous adenofibromatous tumor and prominent micro papillary architecture is not previously reported. We report a case of borderline papillary serous adenofibromatous tumor (also called serous adenocarcinofibroma) with extensive micropapillary pattern in a 27 year-old married woman. She was infertile and presented with diff...

BACKGROUND Lysophosphatidic acid (LPA) governs a number of physiologic and pathophysiological processes. Malignant ascites fluid is rich in LPA, and LPA receptors are aberrantly expressed by ovarian cancer cells, implicating LPA in the initiation and progression of ovarian cancer. However, there is an absence of systematic data critically analyzing the transcriptional changes induced by LPA in ...

Background: Cytological examination of serous body fluids is extremely important since it throws light on the cause, presence of metastatic cells, typing of unknown cases, staging and prognosis of cancer. Aims and Objectives: 1) To study and evaluate current trends in cytological evaluation of serous effusions for various pathological conditions in a tertiary care centre. 2) To analyse their fr...

Advanced high-grade serous ovarian carcinoma is a serious malignant neoplasm with late diagnosis and high mortality rate. Even when treated standard therapy, such as surgery followed by carboplatin paclitaxel chemotherapy, the prognosis remains unfavorable. Immunotherapy treatment alternative that requires further study. Therefore, we aimed to evaluate expression of PD-1, PD-L1, CD8, MSI (MLH1,...

Endometrial cancer (EC) is the most frequent gynecological cancer in developed countries. Most EC occurs after menopause and is diagnosed as endometrioid (type I) carcinomas, which exhibit a favorable prognosis. In contrast, non-endometrioid (type II) carcinomas such as serous tumors have a poor prognosis. Our goal was to identify novel blood-based markers associated with EC subtypes and recurr...

Introduction Borderline ovarian tumors (BOT) constitute 15% of all epithelial ovarian cancers. As the term borderline implies they clinically behave intermediate between benign and malignant tumors. Synonyms of BOT include tumors of borderline malignancy, tumors of low malignant potential, and atypical proliferative tumors (1). Histologically, the borderline tumors are defined by the presence o...

BACKGROUND To investigate the expression of MMP-14 and CD44 as well as epithelial-to-mesenchymal transition(EMT)-like changes in ovarian cancer and to determine correlations with clinical outcome. METHODS In 97 patients with ovarian cancer, MMP-14 and CD44 expression as determined by immunohistochemistry was investigated in relation to EMT-like changes. To determine this, immunohistochemical ...

introduction hydrops fetalis is a serious condition in fetal period, characterized by the presence of serous fluid accumulation in at least two potential spaces in fetus including pleural effusion, pericardial effusion, and ascites. the incidence of hydrops fetalis is one per 2500-3000 pregnancies. this condition is followed by different diseases. fetal hemolytic anemia and its hypoxemia due to...

central serous chorioretinopathy (cscr) is an ocular disease which fluid is collected under retina and leads to retinal detachment and blurred vision. risk factors for development of central serous chorioretinopathy are included: alcohol use, uncontrolled hypertension, pregnancy, type a personalityand different ways of corticosteroid use. we want to present central serous chorioretinopathy in a...

purpose: to evaluate the beneficial effects of rifampin for the treatment of central serous chorioretinopathy (cscr). methods: in this non-randomized clinical trial, 39 patients with acute cscr (<2 weeks) were enrolled. initially, complete visual examinations including determination of best spectacle-corrected visual acuity (bscva) using snellen chart; anterior and posterior segment examination...