to find if some indices have predictive value for renal complications. we conducted a cross sectional and included 80 patients with the age ranged 5-17 years, all with the proven diagnosis of β-thalassemia major. a urine and 5 ml of blood sample were obtained from all of the cases. biochemical indices such as serum levels of creatinine, na, mg, hb, and ferritin and also urine levels of na, mg, ...

During the last decade, a lot of efforts has been made to improve the evaluation of renal functions. Measured Glomerular Filtration Rate (GFR) remains the only valuable test to confirm or confute the status of chronic kidney disease (CKD) and is recommended by Kidney Disease Global Outcomes guidelines when estimation of GFR is not reliable. However, in routine clinical practice, serum creatinin...

This article has not been copyedited and formatted. The final version may differ from this version. Abstract Serum creatinine is commonly used as a marker of renal function but increases in serum creatinine may not represent changes in glomerular filtration rate (GFR). INCB039110 is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1. In a Phase I study, a modest and reversible i...

BACKGROUND This study examines whether the serum concentration of cystatin C (Cys C) correlates with the severity of coronary artery disease (CAD) and whether it provides additional information on the risk for CAD in patients without chronic kidney disease (CKD) estimated by the creatinine-based glomerular filtration rate (GFR). METHODS AND RESULTS The relationship between serum Cys C and the...

Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....

Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....

Renal size and volume decrease with age, accompanied by intrarenal vascular changes. The number of glomeruli decreases and the mass of the juxtamedullary nephrons falls. The result is a decrease in the filtration area of the glomerular basement membrane and decreased permeability. The glomerular filtration rate (GFR) is reduced with aging. The GFR is approximated by the endogenous creatinine cl...

When clinicians speak of kidney function, they almost always are talking about the glomerular filtration rate (GFR). The kidney has many other functions, however. Most excretory functions are related in some way to glomerular filtration, at least as it is modified by the variable reabsorption of water and some solutes and the addition of yet other solutes via secretion. The kidney also has impo...

tem (RAS) such as angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARBs). A review of 1,102 CKD patients from 12 randomized clinical trials clearly showed that in these cases the initial serum creatinine increase associated with RAS inhibitor-based antihypertensive regimens is also followed by slower disease progression [3] . Note that larger shortterm increa...

BACKGROUND AND OBJECTIVE Sporadic cases of renal toxicity have been reported in HIV-infected children treated with tenofovir disoproxil fumarate (TDF). We assessed the long-term renal safety of TDF in a cohort of vertically HIV-infected children, adolescents and young adults. METHODS We evaluated 26 HIV-infected children, adolescents and young adults, aged 4.9-17.4 years at baseline, every 6 ...