Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported....

This study has investigated the chemotactic activity of polymorphonuclear cells (PMNs) isolated from the blood of patients with either articular rheumatoid arthritis (RA) or RA with extra-articular manifestations. A double fluorochrome immunofluorescent staining test has been employed to identify cell-associated immunoglobulins, probably immune complexes. The results suggest an inverse relation...

  Hymenolepiosis is a common intestinal tapeworm infection among children. To Investigate the relation of the level of blood serum immunoglobulins, with hymenolepiosis a study was undertaken at Mean Reza hospital, Mashhad. The blood specimens of  100 patients infected with Hymenolepis Nana who had no other intestinal parasitic infection and were clinically health as cases and 50 healthy person...

Studies in man (1, 2), rabbit (3), and guinea pig (4) have shown that the 18S 71-macroglobu]ins (IgM) are catabolized much more rapidly than 7S 72-globulins (IgG). Thus, immunoglobulin classes may differ in their rates of turnover. Differences in the catabolic control of immunoglobulins are also discernable. The serum level of 7S 7-globulin (IgG) helps to determine the catabolic rate; the highe...

Studies in man (1, 2), rabbit (3), and guinea pig (4) have shown that the 18S 71-macroglobu]ins (IgM) are catabolized much more rapidly than 7S 72-globulins (IgG). Thus, immunoglobulin classes may differ in their rates of turnover. Differences in the catabolic control of immunoglobulins are also discernable. The serum level of 7S 7-globulin (IgG) helps to determine the catabolic rate; the highe...

Fresh sera and concentrated urine from 17 patients with primary Sjögren's syndrome (SS) were fractionated by high-resolution agarose electrophoresis to investigate the presence of monoclonal immunoglobulins or their components. Homogeneous protein bands were found in the gamma-globulin region in 47% of serum samples and 76% of urine specimens of all patients tested. These monoclonal proteins we...

This study was conducted to assess the effect of anti-immunoglobulin antibodies on the measurement of the humoral immune response in hepatitis A virus (HAV) infected patients. Serum samples from 47 patients with acute hepatitis A and from 47 age/sex matched healthy adult subjects were tested for IgA, IgG and IgM by ELISA. Antiimmunoglobulin antibodies were defined using goat immunoglobulins as ...

Iyengar, L., and Selvaraj, R. J. (1972). Archives of Disease in Childhood, 47, 411. Intestinal absorption of immunoglobulins by newborn infants. Intestinal absorption in newbom infants of immunoglobulins present in colostrum was studied by measuring the concentrations of inmunoglobulins IgA, IgG, and IgM in cord blood and following the changes in the serum of the infant on the 5th day after bir...

The quantitation of immunoglobulins in human sera is a common procedure in clinical laboratories and is useful both for clinical and research purposes. Several papers have been published on the subject. Because significant age-related changes occur before adult life, most reports deal with immunoglobulin values in normal children (1-4). However, the data from different laboratories are difficul...