Background: Psoriasis is a common skin disease which beneficiated lately from many new drugs, acting on immunity. Phototherapy remains however a cornerstone of treatment in moderate-to-severe forms. Patients exhibit a continuous and longstanding interest in Dead Sea Climatotherapy (DSC), a well-known off-label psoriasis treatment which demonstrated high rates of success since decades. Objective...

INTRODUCTION The impact of psoriasis varies with the body region affected. In addition, patients have different perceptions of disease improvement and treatment satisfaction based on the location of skin clearance with treatment. The monoclonal antibody secukinumab selectively targets interleukin-17A-a central cytokine of psoriasis-and provides rapid and sustained clearance for moderate-to-seve...

OBJECTIVE To determine whether ultraviolet B phototherapy at home is equally safe and equally effective as ultraviolet B phototherapy in an outpatient setting for patients with psoriasis. DESIGN Pragmatic multicentre single blind randomised clinical trial (PLUTO study). SETTING Dermatology departments of 14 hospitals in the Netherlands. PARTICIPANTS 196 patients with psoriasis who were cl...

Psoriasis is a widespread skin disease affecting up to 2% population with plaque psoriasis accounting to about 80%. It can be identified as a red lesion and for the higher severity the lesion is usually covered with rough scale. Psoriasis Area Severity Index (PASI) scoring is the gold standard method for measuring psoriasis severity. Scaliness is one of PASI parameter that needs to be quantifie...

background and purpose: decision-making process in thoracolumbar and lumbar burst fracture (tlbf) patients with thoracolumbar injury severity and classification score (tlics) > 4 is remained controversial. on the other hand, the question is whether that the oswestry disability index (odi) can be use to assess to clinical outcomes in these patients . we aimed to study the correlation between the...

In the absence of ideal biomarkers, the research for clinical markers correlated to the severity of psoriasis and/or its comorbidities becomes crucial. Recently, studies have shown positive correlation between body mass index and prevalence and severity of psoriasis. Abdominal circumference showed stronger correlation with disease severity than body mass index. We evaluated the waist-to-height ...

BACKGROUND Topical aloe vera (AV) has been used to treat various skin conditions, including psoriasis, with good results. OBJECTIVES This study aims to compare the efficacy of AV and 0.1% triamcinolone acetonide (TA) in mild to moderate plaque psoriasis. METHODS A randomized, comparative, double-blind, 8-week study was designed. Eighty patients randomly received AV or 0.1% TA cream and thei...

BACKGROUND There is a great body of evidence indicating that some inflammatory skin diseases, such as psoriasis, are mediated by oxidative stress. Trace metals have been shown to be involved in oxidative stress response. Altered trace metal homeostasis in psoriasis has been studied. However, limited number of studies has focused on the involvement of metal binding proteins in psoriasis. MATER...

BACKGROUND Beyond their role in hemostasis and thrombosis, platelets are important for modulating inflammatory reactions. Activated platelets play a role in the pathomechanism of inflammatory diseases such as asthma, but little is known about platelet activation in chronic skin inflammation, including atopic dermatitis (AD) and psoriasis. Furthermore, the relationship between platelet activatio...

BACKGROUND Psoriasis is a disease which may have a direct impact on the psychological and social aspects of the patient, particularly due to its visibility. To date, we are unaware of any study showing a relationship between psoriasis and psychological parameters such as psychological vulnerability and coping strategies. OBJECTIVE The aim of this study was to evaluate the effects of psoriasis...