MOTIVATION Although constraint-based flux analysis of knockout strains has facilitated the production of desirable metabolites in microbes, current screening methods have placed a limitation on the number knockouts that can be simultaneously analyzed. RESULTS Here, we propose a novel screening method named FastPros. In this method, the potential of a given reaction knockout for production of ...

We consider the class of linear programs that can be formulated with infinitely many variables and constraints but where each constraint has only finitely many variables. This class includes virtually all infinite horizon planning problems modeled as infinite stage linear programs. Examples include infinite horizon production planning under time-varying demands and equipment replacement under t...

The reproductive value (see Fisher 1930) arises as part of the shadow price of the population in a large class of age-structured optimal control models. 1 Institute of Mathematical Methods in Economics (Research Unit on Operations Research and Control Systems), Vienna University of Technology, Argentinierst. 8, A-1040 Vienna, Austria. E-mail: [email protected]. ac.at and Vienna Institute of Dem...

The paper investigates socially optimal patterns of economic growth and environmental quality in a neoclassical growth model with endogenous technological progress. In the model, the environmental quality affects positively not only to utility but also to production. However, cleaner technologies can be used in the economy whether a part of the output is used in environmentally oriented R&D. In...

Abstract: This paper proposes a centralized data envelopment analysis (DEA) model for industrial optimization based on several different production technologies among several regions. We developed this model based on improved Kuosmanen environmental DEA technology, which avoids positive shadow price on undesirable outputs. We also designed a dual model for our centralized DEA model, and used it...

The Fisher ideal total factor productivity (TFP) index requires complete quantity and price information. If input-output quantities are allocatively efficient, the Fisher index can be approximated by the Malmquist TFP index, which does not require price information. This paper elaborates on the conditions under which the Malmquist and Fisher indexes are equivalent. Drawing from these insights, ...

This paper examines, for a sample of Flemish school leavers, the relation between objective over-education and job satisfaction by applying a shadow price approach. We differentiate between direct effects of over-education and indirect effects via other job characteristics that are associated with over-education. Additional fixed-effects estimates are executed to account for individual heteroge...

The productivity of real-world systems is often limited by so-called bottlenecks. Hence, usually companies are not only interested in finding the best ways to schedule their current resources so that their benefits are maximized (optimization), but, in order to increase the productivity, they also conduct some analysis to find bottlenecks in their system and eliminate them in the most efficient...

While absence of arbitrage in frictionless financial markets requires price processes to be semimartingales, non-semimartingales can be used to model prices in an arbitrage-free way, if proportional transaction costs are taken into account. In this paper, we show, for a class of price processes which are not necessarily semimartingales, the existence of an optimal trading strategy for utility m...