Targeting of proteins to the endoplasmic reticulum (ER) usually requires N-terminal signal peptides (SP) of approximately 22 amino acids in length. However, a substantial number of proteins contain exceptionally long SPs of 40 amino acids and more, an example being protein shrew-1/AJAP1. Using shrew-1's SP as example, the NtraC model has been developed by dissecting long SPs into two functional...

The shrew or RoS attacks are low-rate DDoS attacks that degrade the QoS to end systems slowly but not to deny the services completely. These attacks are more difficult to detect than the flooding type of DDoS attacks. In this paper, we explore the energy distributions of Internet traffic flows in frequency domain. Normal TCP traffic flows present some form of periodicity because of TCP protocol...

In the tree shrew retina individual rod and cone photoreceptors can be readily identified and quantified because their perikarya are arranged in a single layer. This retina is therefore an ideal system for testing the specificity of photoreceptor-directed antibodies. Here we describe the staining properties of polyclonal antibodies against (rhod)opsin and retinal S-antigen in the tree shrew ret...

Reproduction is the most energetically costly process that most female mammals ever undergo. When nutritional resources are scarce, and there is a high probability that females will be unable to cope with this energetic challenge, reproductive processes are inhibited. This process is highly conserved and likely adaptive and reversible when nutritional resources become available. Although the nu...

The distribution and morphology of the digital Pacinian corpuscles in the laboratory house musk shrew, Suncus murinlls, were examined by light and electron microscopes. The Pacinian corpuscles occurred bilaterally along the digital nerves in the 'connective tissue between the flexor digitorum tendons and palmar aspects of the phalanges. They were oval or ellipsoidal in shape and were small, bea...

Neuropeptides are critical signaling molecules, involved in the regulation of diverse physiological processes including energy metabolism, pain perception and brain cognitive state. Prolonged general anesthesia has an impact on many of these processes, but the regulation of peptides by general anesthetics is poorly understood. In this study, we present an in-depth characterization of the hypoth...

The retina of the tree shrew (Tupaia belangeri) is heavily cone dominated, rods comprising less than 4% of the total photoreceptors. Spectral mechanisms and color vision were investigated in this species in both behavioral and electrophysiological experiments. In confirmation of an earlier investigation, the tree shrew was found to have a clear spectral neutral point (at ca 505 nm) and is thus ...

In the tree shrew retina individual rod and cone photoreceptors can be readily identified and quantified because their perikarya are arranged in a single layer. This retina is therefore an ideal system for testing the specificity of photoreceptor-directed antibodies. Here we describe the staining properties of polyclonal antibodies against (rhod)opsin and retinal S-antigen in the tree shrew ret...