Rapid point-of-need assays are used to detect abundant biomarkers. The development of in situ signal amplification reactions could extend these assays to screening and triaging of patients for trace levels of biomarkers, even in resource-limited settings. We, and others, have developed small molecule-based in situ signal amplification reactions that eventually may be useful in this context. Her...

an attempt is made to show in a straightforward way how a body-fixed frame may be constructed in classical and hence in quantum mechanics for a polyatomic molecule with the aid of which the vibration-rotation behavior of the molecule may be described.

Metal nanostructures support plasmon oscillations on their surfaces, which normally decay very quickly. Nevertheless, the lifetime of these can be extended near a longer particle, e.g., molecule. We utilize this phenomenon for ultrahigh (single-molecule) resolution ultrafast apertureless (scattering) applications. demonstrate with numerical solutions 3D Maxwell equations. use nm-sized quantum e...

salicylic acid (sa) is considered to be plant signal molecule that plays a key role in plant growth, development, and defense responses. the physiological mechanism of exogenous sa to affect the senescence of cut lisianthus flowers during vase life was investigated. fresh cut lisianthus flowers were treated with distilled water (control), 0.5, 1 and 2 mm sa and then held at 25◦c up to 12 days. ...

A recent study illustrates an exciting new element of bacteria-host interactions in which the opportunistic pathogen Pseudomonas aeruginosa quorum sensing signal molecule can modulate the host immune system. In this paper, on the basic of a model which describes the competition between bacteria and immune system, a mathematical model is proposed to investigate the modulation of quorum sensing s...

Sterol synthesis by the mevalonate pathway is modulated, in part, through feedback-regulated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). In both mammals and yeast, a non-sterol isoprenoid signal positively regulates the rate of HMGR degradation. To define more precisely the molecule that serves as the source of this signal, we have conducted both pharmacological and g...

We show how one can measure the signal from slow jumps of a single molecule between metastable positions using a setup where the molecule is fixed to one lead and one of the coupling strengths is controlled externally. Such a measurement yields information about slow processes deforming the molecule in times much longer than the characteristic time scales for the electron transport process.

Recent advances in nanophotonics open the way for promising applications towards efficient single molecule fluorescence analysis. In this review, we discuss how photonic methods bring innovative solutions for two essential questions: how to detect a single molecule in a highly concentrated solution, and how to enhance the faint optical signal emitted per molecule? The focus is set primarily on ...

One of the most important mechanisms for bacterial cell-to-cell communication and behaviour coordination under changing environments is often referred to as " quorum sensing " (QS). QS relies on the activation of a sensor kinase or response regulator protein by, in many cases, a diffusible, low molecular weight signal molecule (a " pheromone " or " autoinducer ") (Camara et al., 2002). Conseque...

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