The Ulam sequence is defined as a1 = 1, a2 = 2 and an being the smallest integer that can be written as the sum of two distinct earlier elements in a unique way. This gives 1, 2, 3, 4, 6, 8, 11, 13, 16, 18, 26, 28, 36, 38, 47, . . . Ulam remarked that understanding the sequence, which has been described as ’quite erratic’, seems difficult and indeed nothing is known. We report the empirical dis...

We have systematically analyzed the molecular environment of the signal sequence of a growing secretory protein from Escherichia coli using a stage- and site-specific cross-linking approach. Immediately after emerging from the ribosome, the signal sequence of pOmpA is accessible to Ffh, the protein component of the bacterial signal recognition particle, and to SecA, but it remains attached to t...

Secretory proteins are synthesized with a signal sequence that is usually cleaved from the nascent protein during the translocation of the polypeptide chain into the lumen of the endoplasmic reticulum. To determine the fate of a cleaved signal sequence, we used a synchronized in vitro translocation system. We found that the cleaved signal peptide of preprolactin is further processed close to it...

Intracellular traffic is often controlled not by highways, but by handshakes and partner introductions within a cellular network. Recently determined structures suggest how signal sequences are recognized and how the GTP affinities of the signal recognition particle and its receptor are coupled to the targeting of ribosomes to translocational membrane pores. The structure of signal peptidase su...

Introduction: Aspergillus fumigatus is the leading cause of invasive aspergillosis in immunocompromised patients with a high rate of mortality. Despite introduction of several classes of antifungal drugs, the limitations of current therapies have prompted an intense research toward the discovery of new antifungal compounds. In a recent study, several potential drug targets were identified based...

The thesis describes novel methods for image motion computation and template matching. A multiscale algorithm for energy-based estimation and representation of local spatiotemporal structure by second order symmetric tensors is presented. An efficient spatiotemporal implementation of a signal modelling method called normalized convolution is described. This provides a means to handle signals wi...

Genomic signal processing (GSP) methods which convert DNA data to numerical values have recently been proposed, which would offer the opportunity of employing existing digital signal processing methods for genomic data. One of the most used methods for exploring data is cluster analysis which refers to the unsupervised classification of patterns in data. In this paper, we propose a novel approa...

the analytic signal method is usually used to interpret the magnetic and gravity anomalies. the main advantage of using analytic signal method in interpretation of magnetic source parameters from magnetic anomalies is that the amplitude dip of the analytic signal is independent of directional parameters like magnetization and the dip of the source. using the coefficient of the amplitude to esti...