A single cell creates surprising heterogeneity in a multicellular organism. While every organismal cell shares almost an identical genome, molecular interactions in cells alter the use of DNA sequences to modulate the gene of interest for specialization of cellular functions. Each cell gains a unique identity through molecular coding across the DNA, RNA, and protein conversions. On the other ha...

The quantitative relation between transcription factor concentrations and the rate of protein production from downstream genes is central to the function of genetic networks. Here we show that this relation, which we call the gene regulation function (GRF), fluctuates dynamically in individual living cells, thereby limiting the accuracy with which transcriptional genetic circuits can transfer s...

Ground level upsets have been observed in computer systems containing large amounts of random access memory (RAM). Atmospheric neutrons are most likely the major cause of the upsets based on measured data using the Weapons Neutron Research (WNR) neutron beam.

BACKGROUND There is a controversy regarding the treatment of lumbar disc herniation. Most of patients with lumbar disc herniation and radiculopathy improve with rest and medicine. Lumbar disc surgery gives rapid relief to the patients with severe root pain in legs. This study was conducted to see the risks and benefits of surgery in single level symptomatic lumbar disc disease. METHODS This p...

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

Methods for exerting and measuring forces on single molecules have revolutionized the study of the physics of biology. However, it is often the case that biological processes involve rotation or torque generation, and these parameters have been more difficult to access experimentally. Recent advances in the single-molecule field have led to the development of techniques that add the capability ...

This paper describes the status of the ISocRob MSL robotic soccer team as required by the RoboCup 2011 qualification procedures. The most relevant technical and scientifical developments carried out by the team, since its last participation in the RoboCup MSL competitions, are here detailed. These include cooperative localization, cooperative object tracking, planning under uncertainty, obstacl...

Study cost remains the major limiting factor for genome-wide association studies due to the necessity of genotyping a large number of SNPs for a large number of subjects. Both DNA pooling strategies and two-stage designs have been proposed to reduce genotyping costs. In this study, we propose a cost-effective, two-stage approach with a DNA pooling strategy. During stage I, all markers are evalu...