Abstract Background Single-nucleotide polymorphisms (SNP) of the Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene are associated with higher risk for Crohn′s disease (CD). It has also been reported that they more likely to associate specific phenotypes such as stricturing or perianal and need resection surgery. The aim our study was investigate if these NOD2 variants c...

A novel chip-based detection approach for single-nucleotide polymorphism (SNP) typing based on nanoparticle-coupled DNA-templated ligation reactions is reported. In contrast to conventional methods or recently developed techniques, this approach does not need costly instrumentation and complex stringency washing processes and offers both rapid multiplex SNP detection capability and ultrahigh se...

Melanocortin-4 receptor (MC4R) gene has been known as a candidate gene for growth traits in livestock. This research was aimed to identify the polymorphism of MC4R gene and its association with growth traits in Sumba Ongole (SO) cattle. The growth traits data consist of body weight and body size. Eighty four blood samples were collected and used for DNA isolation. The...

The advent of complete-genome genotyping across phenotype cohorts has provided a rich source of information for bioinformaticians. However the search for SNPs from this data is generally performed on a study-by-study case without any specific hypothesis of the location for SNPs that are predictive for the phenotype. We have designed a method whereby very large SNP lists (several gigabytes in si...

<p>Single Nucleotide Polymorphism (SNP) is the variant on a single nucleotide in genome. Functional SNP, as one of most important molecular markers disease research, has been widely used various research fields, such tumor pathogenesis, diagnosis and treatment, prognostic evaluation, drug development, etc. The number functional SNPs noncoding genome regions much more than that coding regi...

Mimosa bimucronata (Candolle) O. Kuntze, native to the American tropics, is worst invasive tree species in China, where it distributed southern coastal areas of Guangdong and Fujian provinces. It characterized by rapid growth waterlogging resistance, was introduced China for slope bank protection. However, there still a lack effective molecular markers its invasion management. In this study, we...

diabetes mellitus (dm) is a chronic heterogeneous disorder and oxidative stress is a key participant in the development and progression of it and its complications. anti-oxidant status can affect vulnerability to oxidative damage, onset and progression of diabetes and diabetes complications. superoxide dismutase 2 (sod2) is one of the major antioxidant defense systems against free radicals. sod...

adenosine deaminase (ada) is an important regulator of insulin action. the single nucleotide polymorphism (snp) g22a in the ada gene decreases enzymatic activity of ada. the aim of this study was to investigate the relationship between the snp g22a and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (gdm) patients in an iranian population. snp g22a was d...