Purpose Despite the critical role given to small independent retailers (SIRs) in revitalisation of city centres, little knowledge exists about their actual competitive strategies. Existing literature rather is normative, recommending SIRs focus on customer orientation. Thus, aim this study identify types strategies really adopted by SIRs. Design/methodology/approach This qualitative based 13 se...

Objective: First objective of this study was to find out factors influencing development postoperative systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PNL). Secondary point the role preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) in SIRS estimation. Method: The data 756 patients that underwent PNL for kidney stones between 2012 201...

SIRS (systemic inflammatory response syndrome) may result from a wide variety of non-infective insults. Surgery is a recognized cause of SIRS, the onset of which can have adverse prognostic significance. Neutrophil activation is a key histopathological feature of SIRS, and neutrophil clearance through programmed cell death or apoptosis is an essential step in its resolution. Increasingly, it is...

BACKgRoUnD AnD oBJECTIVES: The aim of this study was to identify the incidence of hypophosphatemia in severe traumatic brain injury (TBI), as well as to investigate the causes and its clinical significance. METHoDS: Fifty-nine serum phosphate determination were done in 14 severe TBI in adults RESUlTS: Seven patients developed hypophosphatemia (< 2 mg/dL). Univariate analysis exhibited associati...

Selected repetitive sequences termed short inverted repeats (SIRs) have the propensity to form secondary DNA structures called hairpins. SIRs comprise palindromic arm sequences separated by short spacer sequences that form the hairpin stem and loop respectively. Here, we show that SIRs confer an increase in localized mutability in breast cancer, which is domain-dependent with the greatest mutab...

INTRODUCTION Perioperative systemic inflammatory response syndrome (SIRS) remains a catastrophe in cardiac surgery and adequate patient screening is still lacking. We present a prospective trial starting with preoperative data collection. For the first time, the postoperative outcomes of patients after open-heart surgery are evaluated to predict a hazard-constellation for the patient at risk of...

BACKGROUND Mutations in the BRCA1 and BRCA2 genes are associated with increased risk of breast, ovarian, and several other cancers. The purpose of the present study was to evaluate the incidence of cancer in first- and second-degree relatives of BRCA mutation carriers compared with the general population. MATERIALS AND METHODS A total of 1,086 pedigrees of BRCA mutation carriers was obtained ...

BACKGROUND Since early antimicrobial therapy is mandatory in septic patients, immediate diagnosis and distinction from non-infectious SIRS is essential but hampered by the similarity of symptoms between both entities. We aimed to develop a diagnostic model for differentiation of sepsis and non-infectious SIRS in critically ill children based on routinely available parameters (baseline character...

BACKGROUND Ticagrelor is a reversible and direct-acting oral antagonist of the adenosine diphosphate receptor P2Y12. Possible adenosine-mediated effects of ticagrelor on inflammation are complex and incompletely understood. To our knowledge, ticagrelor-induced systemic inflammatory response syndrome (SIRS) has not yet been described. CASE PRESENTATION We report the case of an 84 years old pat...

Sepsis is a subtype of systemic inflammatory response syndrome (SIRS), which is characterized by infection. Circulating microRNAs (miRNAs), including miR-150, miR-146a and miR-223, are potential biomarkers of sepsis. In this study, we demonstrated that measuring the relative expression of miR-146a/U6 in plasma, using the 2-ΔΔCt method, provides a method for differentiating between sepsis and no...