Measurements and main results: The adjusted odds ratio and 95% confidence intervals (CI) for 28-day mortality rate associated with hypercapnic acidosis defined as day 1 pH <7.35 and PaCO2 >45 mm Hg were 0.14 (95% CI 0.03-0.70, p = .016) in the 12 mL/kg PBW tidal volume group and 1.18 (95% CI 0.59-2.35, p = .639) in the 6 mL/kg PBW tidal volume group. Other definitions of hypercapnic acidosis sp...

In this note, we obtain verifiable sufficient conditions for the extreme value distribution for a certain class of skew product extensions of non-uniformly hyperbolic base maps. We show that these conditions, formulated in terms of the decay of correlations on the product system and the measure of rapidly returning points on the base, lead to a distribution for the maximum of Φ(p) = − log(d(p, ...

In recent years, the skew-normal models introduced by Azzalini (1985)—and their multivariate generalizations from Azzalini and Dalla Valle (1996)—have enjoyed an amazing success, although an important literature has reported that they exhibit, in the vicinity of symmetry, singular Fisher information matrices and stationary points in the profile log-likelihood function for skewness, with the usu...

BACKGROUND Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Following RSV bronchiolitis, 50% of children develop post-bronchiolitis wheeze (PBW). Animal studies have suggested that interleukin (IL)-10 plays a critical role in the pathogenesis of RSV bronchiolitis and subsequent airway hyperresponsiveness. Previously, we showed that ex vivo monocyte IL-10 p...

0168-583X/$ see front matter 2011 Elsevier B.V. doi:10.1016/j.nimb.2011.02.027 ⇑ Corresponding author at: Centro de Micro-Aná Universidad Autónoma de Madrid, Campus de Cant E-28049 Madrid, Spain. E-mail address: [email protected] (M.D. Ynsa). In spite of its recent establishment, proton beam writing (PBW) has already demonstrated to be a highly competitive lithographic technique. PBW is a fast dire...

The aim of the study was to investigate the appropriate home ventilator settings for patients with amyotrophic lateral sclerosis (ALS).In total, 71 patients with ALS, who had received either a noninvasive positive pressure ventilation (NIPPV) or tracheostomy positive pressure ventilation (TPPV), were included. Accordingly, patients were divided into 2 groups (the TPPV and NIPPV groups). We retr...