Incontinence-associated dermatitis (IAD) is a common problem in patients with faecal and/or urinary incontinence. Urine alters the normal skin flora and increases permeability of the stratum corneum and faecal enzymes on the skin contribute to skin damage. Faecal bacteria can then penetrate the skin, increasing the risk of secondary infection. However, IAD can be prevented and healed with timel...

UV radiation poses a significant risk to human health. The mechanisms that help repair UV-damaged cells have recently been more clearly defined with the observation that Toll-like receptor 3 can sense self RNA released from necrotic keratinocytes following UV damage. TLR3 activation in the skin induces inflammation and increases the expression of genes involved in skin barrier repair. Activatio...

The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that microvascular pericytes constitute a cellular link between microvascular damage and fibrosis by transdifferentiating into myofibroblasts. We used a combination of immunohistochemistry and double immunofluorescence labelling of frozen skin biopsi...

Ultraviolet (UV) radiation is the carcinogenic factor in sunlight; damage to skin cells from repeated exposure can lead to the development of cancer. UV radiation has been mainly implicated as the cause of non-melanoma skin cancer, although some role for UV in malignant melanoma has been suggested. The induction of skin cancer is mainly caused by the accumulation of mutations caused by UV damag...

Tanning is the increase in skin pigmentmelanin; it causes the change in color of our skin. Excessive tanning causes skin damage. It is overexposure to the UV rays from the sun. The supreme cause of skin cancer is believed to be the over exposure to the solar radiation which is the medley of ultra-violet radiation (UVA, UVB, and UVC), and visible light. UVB is the stronger component amongst the ...

BACKGROUND Previous experimental studies showed that single ultraviolet B (UVB) light irradiation increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a well-established biomarker of carcinogenesis and oxidative DNA damage, in epithelial cells in animals and humans. We conducted for the first time an epidemiologic study to investigate the correlations among levels of oxidative DNA damage, ...

Several attempts have been made to enhance skin permeation by chemical, physical, or mechanical methods to overcome barrier properties of skin. The present study demonstrates the ability of non-thermal plasma to increase skin permeation and enhance transdermal delivery of large molecules including liposomes (100 nm), nanoparticles (50 nm) & proteins (115 kDa) to deeper layers of the skin rapidl...

Background Consumption of tart cherry juice has been reported to effectively reduce inflammation, muscle damage, and muscle soreness following bouts of exercise. The purpose of this study was to determine if consumption of a powdered form of tart cherries derived from tart cherry skins prior to and following intense endurance exercise promotes similar positive results as seen with tart cherry j...

Background Consumption of tart cherry juice has been reported to increase subsequent resistance exercise performance by reducing inflammation and oxidative stress that cause secondary muscle damage following initial bouts of resistance exercise. The purpose of this study was to determine if consumption of a powdered form of tart cherries derived from tart cherry skins (CherryPURE Freeze Dried T...