Background Skin prick testing and serum food-specific IgE testing are the most commonly used diagnostic tests in evaluating IgE-mediated food reactions. However, the presence of negative tests can be falsely re-assuring such outcomes do not always exclude allergy. Food challenges are therefore indicated. Double-blind, placebo-controlled food challenge is the gold standard for diagnosis, but in ...

Heparins are one of the most used class of anticoagulants in daily clinical practice. Despite their widespread application immune-mediated hypersensitivity reactions to heparins are rare. Among these, the delayed-type reactions to s.c. injected heparins are well-known usually presenting as circumscribed eczematous plaques at the injection sites. In contrast, potentially life-threatening systemi...

Allrgic reaction to natural rubber latex have increased during past 10 years especially among health worker and patients with high exposure to latex allergen. Latex allergy is associsted with clinical or serological cross reactivity to plant derived food allergcn especially tropical fruit for example avocado bannana chestnut kiwi papaya potato and peaches. In this study on health worker among 5...

OBJECTIVE The aim of our study was to determine the diagnostic usefulness of a newly developed basophil activation test (BAT) in patients allergic to Dermatophagoides pteronyssinus and pollens. We also analyzed the influence of cetirizine on CD63 upregulation. This popular antihistamine strongly inhibits skin tests, but its impact on BAT sensitivity remains unknown and deserves at least prelimi...

BACKGROUND Exposure to allergens in early life may predispose subjects to develop allergies and diseases related to allergic sensitisation. OBJECTIVE To determine the association between month of birth and atopic sensitisation in adult Turkish patients with rhinitis and/or asthma using the diagnostic method of skin prick tests. METHODS This prospective cross-sectional study included all adu...

BACKGROUND The ability to mount an IgE response to allergens is a prerequisite for the development of positive allergen skin tests. Histamine is commonly used as a positive control in skin prick testing and provides a measure of nonspecific skin reactivity, similar to bronchial hyper-responsiveness. METHODS To determine whether allergen responsiveness, age, gender and season of the year contr...

the  frequency of  allergic diseases such  as allergic rhinitis is considerable in general population. insect aeroallergens are important allergens which can induce airway inflammation. the aim of this study was to determine the prevalence of sensitization to insect aeroallergens in allergic rhinitis patients in yazd as a desert city in iran. a cross-sectional study was undertaken on 95 allergi...

Skin prick testing is an essential test procedure to confirm sensitization in IgE-mediated allergic disease in subjects with rhinoconjunctivitis, asthma, urticaria, anapylaxis, atopic eczema and food and drug allergy. This manuscript reviews the available evidence including Medline and Embase searches, abstracts of international allergy meetings and position papers from the world allergy litera...