نتایج جستجو برای: small molecule compounds

تعداد نتایج: 1091619  

Journal: :Chemical communications 2008
Michaël Davi Hélène Lebel

A novel multicatalytic one-pot process providing trans-cyclopropyl compounds from corresponding aldehydes has been developed and applied to the synthesis of GPR40 small molecule agonists.

2014
Birgit Hoeger Maren Diether Pedro J. Ballester Maja Köhn

Computationally supported development of small molecule inhibitors has successfully been applied to protein tyrosine phosphatases in the past, revealing a number of cell-active compounds. Similar approaches have also been used to screen for small molecule inhibitors for the cancer-related phosphatases of regenerating liver (PRL) family. Still, selective and cell-active compounds are of limited ...

Journal: :Genome Biology 2002

Journal: :Nature Methods 2020

2017
Ronald Bartzatt Preeti Sule Suat L.G. Cirillo Jeffrey D. Cirillo Suat L. G. Cirillo

Aims: To demonstrate the efficacy of five small molecule compounds for inhibiting the growth of Mycobacterium tuberculosis. To present evidence that these compounds will penetrate into the central nervous system. Study Design: Five small molecule compounds bearing a hydrazide group were synthesized utilizing microwave excitation. These compounds were then placed into tissue culture with Mycobac...

2015
Takahiro Iwao Nao Kodama Yuki Kondo Tomoki Kabeya Katsunori Nakamura Takashi Horikawa Takuro Niwa Kouichi Kurose Tamihide Matsunaga

The small intestine plays an important role in all aspects of pharmacokinetics, but there is no system for the comprehensive evaluation of small-intestinal pharmacokinetics, including drug metabolism and absorption. In this study, we aimed to construct an intestinal pharmacokinetics evaluation system and to generate pharmacokinetically functional enterocytes from human induced pluripotent stem ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2015
Takahiro Iwao Nao Kodama Yuki Kondo Tomoki Kabeya Katsunori Nakamura Takashi Horikawa Takuro Niwa Kouichi Kurose Tamihide Matsunaga

The small intestine plays an important role in all aspects of pharmacokinetics, but there is no system for the comprehensive evaluation of small-intestinal pharmacokinetics, including drug metabolism and absorption. In this study, we aimed to construct an intestinal pharmacokinetics evaluation system and to generate pharmacokinetically functional enterocytes from human induced pluripotent stem ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید