OBJECTIVE To describe trends and determinants of severe morbidity in HIV-infected women and men. DESIGN A French prospective cohort of HIV-infected patients of both sexes and all transmission categories. METHODS We used hospital admission data from January 2000 to December 2008. A severe morbid event (SME) was defined as a clinical event requiring hospitalization for ≥48 h, several events c...

The main goal of this research was to compare the in vitro release rates of nano- and microcapsules of Silybum marianum extract (SME) in animal simulated gastric and intestinal medium conditions. The extract was encapsulated within sodium alginate carriers using emulsification/internal gelation method. Particle size, zeta potential, polydispersity index (PDI) and morphology of...

Purpose – The purpose of this paper is to contribute to the implementation of best practices of collaboration between university and industrial smalland medium-sized enterprises (SMEs). Design/methodology/approach – This paper presents the experience carried on by a university group fostering the collaboration with SME companies involving young engineering students and researchers in projects d...

OBJECTIVE: The aim of this randomized clinical trial was to evaluate the dental, dentoalveolar, and skeletal changes occurring right after the rapid maxillary expansion (RME) and slow maxillary expansion (SME) treatment using Haas-type expander. METHODS: All subjects performed cone-beam computed tomography (CBCT) before installation of expanders (T1) and right after screw stabilization (T2)....

BACKGROUND Vincristine (VCR), which is a widely used antineoplastic drug, was integrated with a submicron-emulsion drug-delivery system to enhance the anticancer effect. METHODS After the formation of a VCR-oleic acid ion-pair complex (VCR-OA), the VCR-OA-loaded submicron emulsion (VCR-OA-SME), prepared by classical high-pressure homogenization, was characterized and its in vitro anticancer e...

Lithium complexes bearing mono-anionic aminophenolate ligands are described. Reactions of ligand precursors HON(Me)Ph(OMe), HON(Me)Ph(SMe), HON(Me)C(OMe) or HON(Me)C(NMe2) [HON(Me)Ph(OMe) = (2-OMeC6H4CH2)N(Me)(CH2-2-HO-3,5-C6H2((t)Bu)2); HON(Me)Ph(SMe)= (2-SMe-C6H4CH2)N(Me)(CH2-2-HO-3,5-C6H2((t)Bu)2); HON(Me)C(OMe) = (MeOCH(2)CH2)N(Me)(CH2-2-HO-3,5-C6H2((t)Bu)2); HON(Me)C(NMe2) = (Me2NCH2CH2)N(...

Analogy and similarity are central phenomena in human cognition, involved in processes ranging from visual perception to conceptual change. To capture this centrality requires that a model of comparison must be able to integrate with other processes and handle the size and complexity of the representations required by the tasks being modeled. This paper describes extensions to Structure-Mapping...

Situational method engineering (SME) is an established approach to create situated methods which allows the systematic construction of software artifacts while considering specific project context and goals. The author’s motivation is to investigate whether and how SME can be applied to Information Systems management (ISM), i.e., if SME concepts can be extended in order to create situated ISM m...