hepatitis c virus is one of the main reasons for chronic liver disease and hepatocellular carcinoma. combination therapy with interferon (peg-ifn-α) and ribavirin (rbv) clear the virus more likely than the others. different factors like virus and host characteristics influence on response to treatment. the most important viral factors include virus genotype and viral load; host factors like gen...

BACKGROUND Using a linkage disequilibrium (LD)-based approach, we sought to comprehensively define common genetic variation at the plasminogen activator inhibitor-1 (PAI-1) locus and relate common single nucleotide polymorphisms (SNPs) and haplotypes to plasma PAI-1 levels. METHODS AND RESULTS In reference pedigrees, we defined LD structure across a 50-kb genomic segment spanning the PAI-1 lo...

Allele-specific polymerase chain reaction (AS-PCR) is a rapid and cost-effective single nucleotide polymorphism (SNP) genotyping method compared to multiplex or real-time PCR. The SNPs occurring in mitochondrial DNA (mtSNPs) the most abundant humans can be used human identification involving mass fatality incidents. Nevertheless, application of AS-PCR has yet widely applicable forensic investig...

In the previous issue of Critical Care, Behnes and colleagues [1] provide an interesting commentary on our study showing that septic patients with the T-allele in 372 T/C (rs4898) genetic polymorphism of the tissue inhibitor of metalloproteinase-1 (TIMP-1) had higher mortality and higher TIMP-1 serum levels than those without it [2]. As the authors state in their commentary, our study had some ...

The aim of this study was to investigate influence of the NFE2L1 gene polymorphisms on some parameters of meat production in sheep. Polymorphisms of the NFE2L1 gene were detected using NimbleGen sequencing technology (Roche, USA). The effect of polymorphisms identified was investigated in Manych Merino sheep breed. In coding and regulatory parts of gene 11 single nucleotide polymorphisms (SNP) ...

BACKGROUND An association between lung cancer and chemokines has been advocated in the recent years. This study aims at investigating the association between lung cancer and 16C/A single nucleotide polymorphism (SNP) (rs. 4359426) in C-C motif chemokine 22 (CCL22) as well as C1014T SNP (rs. 2228428) in C-C chemokine receptor type 4 (CCR4), which serves as the receptor for CCL22. METHODS Genot...

Background: Endometriosis is one of the most common benign gynecological diseases which is characterized by endometriallike tissue growing outside the uterine cavity. Although the pathology of endometriosis remains unknown, the genetic predisposition plays an apparent role. Several genes have been contributed to endometriosis, but it seems KRAS has a crucial role, because its activation results...

The number of teats is a crucial reproductive trait with significant economic implications on maternal capacity and litter size. Consequently, improving this essential to facilitate genetic selection for increased In study, we performed genome-wide association study (GWAS) the in three-way crossbred commercial Duroc × (Landrace Yorkshire) (DLY) pig population comprising 1518 animals genotyped 5...

Objective: The aim of this study was to explore if the single nucleotide polymorphism (SNP) IL-6 related susceptibility, severity neurological deficit and recurrence risk cerebral infarction (CI). Methods: Three hundred eighty-two patients with CI 385 healthy controls were selected for gene promotor region-174G /C, -572C/G, -597G/A by SNaPshot SNP typing. National Institute Health Stroke Scale ...

INTRODUCTION A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. METHODS A case-control study was conducted among 30 patients ...