Membrane-type 1 matrix metalloproteinase (MT1MMP/MMP-14) is a key enzyme involved in degradation of extracellular matrix (ECM) and various surface-associated proteins that control cell growth, differentiation and survival, plays crucial roles in molecular carcinogenesis, tumor cell growth, invasion, and angiogenesis. We tested the inhibitory effect of antisense MT1-MMP on the ability of metasta...

Wei Wang, Yujie Cui, Jianzhong Shen, Jingjing Jiang, Shenghan Chen, Jianhao Peng and Corin Variant Identified in Blacks Salt-Sensitive Hypertension and Cardiac Hypertrophy in Transgenic Mice Expressing a Print ISSN: 0194-911X. Online ISSN: 1524-4563 Copyright © 2012 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dall...

An efficient method is proposed to perform global sensitivity analysis of a the computer model of a physical system whose input parameters are random. The so-called sensitivity indices are usually computed by Monte Carlo simulation, which reveals inappropriate for industrial applications due to an unaffordable computational cost. In the present paper, polynomial chaos (PC) expansions are introd...

Sensitivity analysis aims at quantifying influence of input parameters dispersion on the output dispersion of a numerical model. When the model evaluation is time consuming, the computation of Sobol' indices based on Monte Carlo method is not applicable and a surrogate model has to be used. Among all approximation methods, polynomial chaos expansion is one of the most efficient to calculate var...

A new approach for a global sensitivity analysis of nonlinear mathematical models is presented using the information provided by two complementing variance-based methods. As a first step, the model is evaluated applying a shared sampling strategy for both methods based on Sobol’s quasi-random sequences. Then, total sensitivity indices are estimated in a second step using the Sobol’-Saltelli met...

The GARCH model has been successful in describing the volatility dynamics of asset return series. However, tree-based GARCH option pricing algorithms suffer from exponential running time, inaccuracy, or other problems. Lyuu and Wu proved that the trinomial-tree option pricing algorithms of Ritchken and Trevor (1999) and Cakici and Topyan (2000) explode exponentially when the number of partition...

Sobol, and seminar participants at the September 1999 Brookings Panel for helpful comments. Scott Nicholson has provided excellent research assistance. The views expressed here are those of the authors, and do not necessarily reflect those of the Federal Reserve Bank of New York, the Federal Reserve System, or any other institution with which the authors are affiliated.

An adaptive Monte Carlo strategy for computing global Sobol ́ sensitivity indices has been presented and discussed. The experimental scheme including an approximation tool, variance-based approaches for sensitivity analysis and Monte Carlo technique for multidimensional integration has been described and studied.

This article presents an analysis of the secure key broadcasting scheme proposed by Wu, Ruan, Lai and Tseng [11]. The study of the parameters of the system is based on a connection with a special type of symmetric equations over finite fields. We present two different attacks against the system, whose efficiency depends on the choice of the parameters. In particular, a time-memory tradeoff atta...