Objective: Huntington’s disease (HD) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social cognition in a ...

This study is to test the hypothesis that apathy in healthy participants is closely related to the prefrontal-basal-ganglia circuit and associated structural changes. We selected 36 healthy aged participants with (n = 18) or without apathy (n = 18) from our database. Participants underwent structural MRI scanning, providing data for voxel-based morphometric analysis to explore gray matter chang...

BACKGROUND Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described. METHODS We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. RESULTS There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingul...

OBJECTIVES Executive and behavioural changes are well-recognised in classical amyotrophic lateral sclerosis (ALS), indicating a subclinical behavioural-variant frontotemporal dementia (bvFTD) in some patients. Social cognitive deficits in ALS have been recently described and an impairment was identified on a simple Theory of Mind (ToM) test, which assesses the judgement of the preference of ano...

Recommended Citation Calamia, Matthew. "Measuring apathy in a neuropsychological patient sample : factor structure and clinical correlates." PhD (Doctor of Philosophy) thesis, ii To my family iii ACKNOWLEDGMENTS First, I would like to thank my advisors, Dan Tranel and Kristian Markon. Dan gave me the freedom to pursue my own research interests throughout my time at Iowa, helped me through the u...

Objectives: Fatigue and apathy are two of the most common and most disabling non-motor symptoms of Parkinson’s disease (PD). They have a high coincidence and can often be confused; moreover, their relationship is not fully understood. The aim of our study was to describe the coincidence of apathy with different fatigue domains in the presence/ absence of depression and to separately describe th...

BACKGROUND The relationship between apathy, depression and cognitive impairment in Parkinson's disease (PD) is still controversial. The objective of this study is to investigate whether apathy and depression are associated with inefficient cognitive strategies in PD. METHODS In this prospective clinical cohort study conducted in a university-based clinical and research movement disorders cent...

South African courts have recently accepted social psychological phenomena as extenuating factors in murder trials. In one important case, eight railway workers were convicted of murdering four strike breakers during an industrial dispute. The court accepted conformity, obedience, group polarization, deindividuation, bystander apathy, and other well-established psychological phenomena as extenu...

Apathy is a relatively common clinical feature of HIV-Associated Neurocognitive Disorders, but little is known about its implications for everyday functioning outcomes. In the present study, we examined the associations between apathy and self-reported instrumental activities of daily living (IADL) and neurocognitive complaints in 75 participants with HIV infection and 52 demographically compar...