OBJECTIVES To evaluate the merit of a new alginate efficacy film test to determine the bactericidal activity of the high-level disinfectant ortho-phthalaldehyde (OPA). METHODS The efficacy of OPA was investigated using a new sodium alginate surface film test against Mycobacterium chelonae NCIMB 1474 and Epping, and Pseudomonas aeruginosa NCIMB 10421 under different test conditions. RESULTS ...

In the present work, a gastroretentive in situ gelling liquid formulation for controlled delivery of ranitidine was formulated using sodium alginate (low, medium and high viscosity grades), calcium carbonate (source of cations) and ranitidine. Prepared formulations were evaluated for viscosity, buoyancy lag time and buoyancy duration, drug content and in vitro drug release. Formulation variable...

Embryogenic callus culture of carrot (Daucus carota L.) was induced from the hypocotyl explants in MS medium supplemented with Casein hydrolysate, 2,4-D and BAP for somatic embryogenesis In vitro cell suspension cultures for high multiplication rate. Embryogenic callus was transferred to liquid basal Murashige and Skoog medium The mature somatic embryos were encapsulated in a Sodium alginate mi...

BACKGROUND AND THE PURPOSE OF THE STUDY Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects. METHODS Diclofenac sodium loaded alginate-PVP K 30...

The purpose of the research was to formulate microspheres of acyclovir (ACV) using mucoadhesive polymers, sodium alginate and chitosan. Calcium chloride was used as the ionotropic gelling agent. Sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. Chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...

The advancement of clinical medicine established exceptionally in today’s era is used to cure many infectious diseases. Unfortunately, the negative aftermath associated with synthetic drugs has caused turn their attention towards an alternative, which natural plant-extract drugs. Plant-based have a vast number benefits and applications biomedical field are further formulated nanocomposite hydro...

The present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic rifampicin. Ionotropic gelation method was applied to prepare beads using calcium chloride (CaCl2) as cationic component and alginate as an anionic component. In this method, adding 0.5% w/v polyvinyl alcohol (PVA) t...

Shoot tips excised from shoot culture of Salvia officinalis were encapsulated in 2% or 3% (w/v) sodium alginate and exposed to 50 mM calcium chloride for complexation. Immediately or after 6, 12 or 24 weeks of storage at 4°C, the synthetic seeds were cultured for 6 weeks on half-strength MS medium supplemented with indole-3acetic acid (IAA) (0.1 mg/l) and solidified with 0.7% agar. The frequenc...

BACKGROUND The study aimed to evaluating the effect of disinfecting impression materials on the dimensional accuracy and surface quality of the resulting casts. METHODS Impressions of a steel die constructed according to ANSI/ADA specification No.18 were made with each of alginate, addition cured silicone, condensation cured silicone and zinc oxide eugenol paste, and disinfected consequently ...

Different types of in situ gelling systems of indomethacin, in sodium alginate vehicle, were prepared and evaluated for their pharmaceutical properties including viscosity, sterility and drug content uniformity. The gelling efficacy of the prepared systems was evaluated by using an in house fabricated gelation cell. The in vitro release kinetics of the prepared systems was determined in simulat...