Pyridoxylated normal adult human hemoglobin (HbAo) has been prepared using both oxygenated and deoxygenated HbAo at pH 6.8 and room temperature without the addition of Tris to produce a mixture with P50 of 30 +/- 2 torr and a Hill coefficient of 2.3 +/- 0.1 similar to that of the isolated adult human hemoglobin from the red blood cell. Reduction of the pyridoxylated HbAo in the oxygen-ligated f...

A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic β-ketophosphonates that on reduction with sodium borohydride gave the required indolones in goo...

A new series of N,N'-bis(2'-hydroxy-5'-substituted-benzyl)-N,N -dimethylethane-1,2-diamines (N,N'-dimethyltetrahydrosalen) ligands were prepared in good yield by reduction of the respective 3,3'-ethylene-bis(3,4-dihydro-6-substituted-2H-1,3-benzoxazine) precursors with sodium borohydride . The ligands were characterized by IR, NMR, and elemental analysis, which showed the compounds to be consis...

From the time immemorial, sodium borohydride has been used for the reagent of choice for reducing various carbonyl compounds and acid chlorides in protic solvents. Over the past decades the utility of sodium borohydride has been greatly expanded and various modifications have been developed. Reductive dechlorination of aromatic halo nitro compounds have a great significance in the field of orga...

Worldwide, hydrogen is gaining ground since it a promising alternative energy source to conventional fuels, which include fossil fuel. Thus, numerous techniques generate have been suggested. This literature review describes the challenges and obstacles identified through series of publications that target hydrolysis sodium borohydride. present several catalysts reactor systems for generation ga...