Ingesting sodium nitrite as a suicide method appears to be gaining popularity, spurred by online blogs and an easily obtainable product. However, the exact nature of this trend has not been...

Recent research suggests the vivid possibility of using nitrite therapy against various pathological conditions. Moreover, chronic nitrite therapy offers protection against ischemia and augments endothelial cell proliferation through unknown mechanisms. Nitrite-mediated augmentation in the number of circulating neutrophils has also been reported; however, the exact mechanism is not known. In th...

in april, 2013, a suzhou hospital reported a nitrite intoxication patient in coma as well as 2 family members with the similar symptom 5 days ahead. we investigated the event to identify the cause, source and possible pollution ways of the contamination.we defined case as any person living in yshy community who has cyanosis and with at least one of the following symptoms: dizziness, headache, f...

AIM Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we ...

Background and objective: Nitrite is one of the most common environmental contaminants affecting Extracellular Matrix (ECM) proteins expression. Drinking water contains different concentrations of nitrite and nitrate. Therefore, consumption of water contaminated with sodium nitrite can lead to infertility. This study aims to investigate the effects of oral administration of sodium nitrite on ex...

We thank Kruszelnicka and Surdacki (1) for their insightful comments on our recent article (2), which suggested a favorable metabolic effect of endothelial nitric oxide (NO) that stimulates the polarization of hepatic resident macrophages toward an anti-inflammatory M2 phenotype. Kruszelnicka and Surdacki ask whether the nitrate-nitrite pathway exerts beneficial metabolic effects in the liver. ...

The reactions of human hemoglobin with sodium nitrite and ethyl nitrite in deoxygenated media have been examined in kinetic detail. Nitrous acid has been identified from kinetic pH dependence studies as the principal oxidant of hemoglobin in reactions with sodium nitrite. Nitrosylhemoglobin is produced concurrently with methemoglobin as a result of reductive release of nitric oxide from nitrous...