In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relati...

Delivery of drugs and nanomedicines to tumors is often heterogeneous insufficient and, thus, limited efficacy. Microbubbles in combination with ultrasound have been found improve delivery tumors, enhancing accumulation penetration. We used a subcutaneous prostate cancer xenograft model mice investigate the effect free nanoparticle-encapsulated cabazitaxel microbubbles lipid shell or nanoparticl...

To enhance tumor magnetic resonance imaging (MRI) signals via the selective accumulation of contrast agents, we prepared folate-modified gadolinium-lipid-based nanoparticles as MRI contrast agents. Folate-modified nanoparticles were comprised of polyethylene glycol (PEG)-lipid, gadolinium diethylenetriamine pentaacetic acid lipid, cationic cholesterol derivatives, folate-conjugated PEG-lipid, a...

Although sildenafil citrate (SC) is used extensively for erectile dysfunction, oral delivery of SC encounters many obstacles. Furthermore, the physicochemical characteristics of this amphoteric drug are challenging for delivery system formulation and transdermal permeation. This article concerns the assessment of the potential of nanomedicine for improving SC delivery and transdermal permeation...

CONTEXT Over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. Absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric pH and digestive enzymes. EVIDENCE ACQUISITION Recent reports have identified and explained the beneficial role of several struct...

to resolve handling problem of nanoparticles, due to their small size, a new methodology of electro-spraying and freeze-drying was developed for colloidal nanoparticles of silica and titania to transform them to solid macro-scale nanoparticle assemblies.  the assemblies were then redispersed in an aqueous system to investigate the effect of formulation of original solutions and the process para...

In this study we investigate silica nanoparticle (SiO2NP) effects on the structure and phase properties of supported lipid monolayers and bilayers, coupling surface pressure measurements, fluorescence microscopy and atomic force microscopy. SiO2-NPs typically in size range of 10nm to 100 nm in diameter are tested. Our results suggest first that lipid molecules organization depends to their natu...

We aim to prepare a size-shifting nanocarrier for site-targeting mucosal drug delivery that can penetrate through mucus gel layer and remain close the absorption membrane. As nanocarriers be engineered but they also back diffuse into outer regions, size shifting micron range once have reached membrane would prevent back-diffusion effect extend release over long period of time. For this purpose,...