Ets transcription factors play crucial roles in regulating diverse cellular processes including cell proliferation, differentiation and survival. Coordinated regulation of the Drosophila Ets transcription factors YAN and POINTED is required for eliciting appropriate responses to Receptor Tyrosine Kinase (RTK) signaling. YAN, a transcriptional repressor, and POINTED, a transcriptional activator,...

Mulberry anthocyanins possess many pharmacological effects including liver protection, anti-inflammation, and anticancer. The aim of this study was to evaluate whether mulberry anthocyanin extract (MAE) exerts beneficial effects against oxidative stress damage in HepG2 cells and Caenorhabditis elegans. In vitro, MAE prevented cytotoxicity, increased glucose consumption and uptake, and eliminate...

Vitamin A deficiency (VAD) is the most common cause of childhood blindness in the developing world. It is estimated that by giving adequate vitamin A, in vitamin A deficient populations, child mortality from measles can be reduced by 50%, and mortality from diarrheal disease by 40%. Overall mortality in children 6-59 months of age can be reduced by 23%. This paper reported results from a study ...

Isoprene is a substantial contributor to the global secondary organic aerosol (SOA) burden, with implications for public health and the climate system. The mechanism by which isoprene-derived SOA is formed and the influence of environmental conditions, however, remain unclear. We present evidence from controlled smog chamber experiments and field measurements that in the presence of high levels...

PURPOSE Retinal neovascularization occurs under the influence of angiogenic factors like vascular endothelial growth factor (VEGF). VEGF signaling is enhanced by insulin-like growth factor-1 (IGF-1). In vitro, the oxoindolinone MAE 87 inhibits angiogenic signal transduction by blocking tyrosine kinase receptors including VEGF receptor 2 (VEGFR-2), IGF-1R, fibroblast GF-1R and epidermal GFR. We ...

The widely accepted disinhibition theory of the motion after-effect (MAE) proposes that the balance point of an opponent mechanism is changed by directional adaptation. To see if the post-adaptation balance point could be predicted from contrast adaptation, we measured threshold-vs-contrast (i.e., T-vs-C or dipper) functions, before and after adaptation to moving gratings. For test stimuli movi...

We measured the magnitude of the motion after effect (MAE) elicited by gratings viewed through four spatial apertures symmetrically positioned around fixation. The gratings were identical except for their orientations, which were varied to form patterns of global motion corresponding to radiation, rotation or translation. MAE magnitude was estimated by three methods: the duration of the MAE; th...

The renewed interest in plant-derived drugs has led to an increased need for efficient extraction methods. The present investigation was an attempt to evaluate and compare the conventional methods of extraction with non conventional methods of extraction, such as ultrasonic-assisted extraction (UAE) and microwave-assisted extraction (MAE) methods. Pterocarpus marsupium Roxb. has been reported t...

A modeling technique based on absorbed microwave energy was proposed to model microwave-assisted extraction (MAE) of antioxidant compounds from cocoa (Theobroma cacao L.) leaves. By adapting suitable extraction model at the basis of microwave energy absorbed during extraction, the model can be developed to predict extraction profile of MAE at various microwave irradiation power (100-600 W) and ...