The relationship between negative affectivity (NA, i.e. the Neuroticism trait and transient distress), self-reported medical condition and somatic complaints was assessed in structural equation models also including personality (the Big Five personality domains), socio-demographic, and health behaviour variables. The results indicated that the individual's current distress level and medical con...

BACKGROUND The Psychiatric Case Register Middle Netherlands (PCR-MN) registers the mental healthcare consumption of over Dutch 760,000 inhabitants in the centre of the Netherlands. In 2010 the follow-up period was over ten years. In this paper we describe the content, aims and research potential of this case register. DESCRIPTION All mental healthcare institutions in the middle-western part o...

The time evolution of the Partridge-Barton model in the presence of the pleiotropic constraint and deleterious somatic mutations is exactly solved for arbitrary fecundity in the context of a matricial formalism. Analytical expressions for the time dependence of the mean survival probabilities are derived. Using the fact that the asymptotic behavior for large time t is controlled by the largest ...

Substitution rates vary between species, and many explanations regarding the causes of this variation have been proposed. Here we consider how new genomic data on the per-generation mutation rate impinge on proposed hypotheses for substitution rate variation in primates. We propose that the generation-time effect as it is usually understood cannot explain the observed rate variation, but instea...

Substitution rates vary between species, and many explanations regarding the causes of this variation have been proposed. Here we consider how new genomic data on the per-generation mutation rate impinge on proposed hypotheses for substitution rate variation in primates. We propose that the generation-time effect as it is usually understood cannot explain the observed rate variation, but instea...

abstract: mastitis is an inflammatory reaction of the mammary tissue in response to the introduction and multiplication of pathogens and is characterized by increasing somatic cell count (scc) in milk. the main objective of present study is to assess the probable associations between somatic cell (sc) levels and calcium and phosphorus and ratio of ca/p in raw milk. milk samples were collected f...