the existence of some geometrically imperfect members, like initial curvature in a double layer space structures with hundreds or thousands of members is almost inevitable. these imperfections give rise to loss of load bearing capacity of double layer space structures. to evaluate the effect of initial member imperfection on load bearing capacity of double layer space structures and their failu...

In the present article, we revisit question of structural characteristics and building methods two most famous Hungarian Late-Gothic net vaults, nave vault Franciscan Church Szeged-Alsóváros Reformed Nyírbátor. Based on data gathered by laser-scanning buildings, geometric system as opposed to former state research, differ significantly from each other. While rib webbing have features characteri...

Thermoascus aurantiacus xylanase is a thermostable enzyme which hydrolyses xylan, a major hemicellulose component of the biosphere. The crystal structure of this F/10 family xylanase, which has a triosephosphate isomerase (TIM) barrel (beta/alpha)(8) fold, has been solved to small-molecule accuracy at atomic resolution (1.11 A) at 293 K (RTUX) and at ultrahigh resolution (0.89 A) at 100 K (CTUX...

Spontaneous membrane insertion and folding of beta-barrel membrane proteins from an unfolded state into lipid bilayers has been shown previously only for few outer membrane proteins of Gram-negative bacteria. Here we investigated membrane insertion and folding of a human membrane protein, the isoform 1 of the voltage-dependent anion-selective channel (hVDAC1) of mitochondrial outer membranes. T...

Auguste Fabre was a French contractor specialized in the construction of masonry vaults. He founded his company 1896 and patented different systems light economic vaults, among them one for tile built thousands vaults France, Belgium Algeria, some great importance, such as dome Petit Palais international exhibition Paris 1900, or Congo Museum Tervuren (Belgium). Historicism breeding ground howe...

We probe the stability and near-native energy landscape of protein fold space using powerful conformational sampling methods together with simple reduced models and statistical potentials. Fold space is represented by a set of 280 protein domains spanning all topological classes and having a wide range of lengths (33-300 residues) amino acid composition and number of secondary structural elemen...

The h-barrel is a transmembrane structural motif commonly encountered in bacterial outer membrane proteins and pore-forming toxins (PFTs). a-Hemolysin (aHL) is a cytotoxin secreted by Staphylococcus aureus that assembles from a water-soluble monomer to form a membrane-bound heptameric h-barrel on the surface of susceptible cells, perforating the cell membranes, leading to cell death and lysis. ...

Abstract The paper presents a diagnosis of damage to heritage structures based on the case historic church in Ko?uchów. Church Purification Blessed Virgin Mary dates back thirteenth century and is an important sacral building south-west Poland. Renovation strengthening works have been conducted recent years with goal structurally stabilizing building. includes short history building, as well re...