نتایج جستجو برای: spatial reference memory
تعداد نتایج: 851112 فیلتر نتایج به سال:
Background & Objective: The axial role of the oxidative stress in the pathophysiology of Parkinson disease has been identified. On the other hand, the learning and memory impairment in Parkinson disease has a distinguished outlook. Since Saffron has antioxidative stress effects, the aim of the present study is to investigate the improving effects of Saffron extract on the spatial memory paramet...
Introduction: Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain. Methods: Orofacial...
Background and Objective: Diabetes mellitus is a complicated metabolic disorder that can impair both spatial learning and memory. The aim of this study was to evaluate the effect of zinc and melatonin supplements on spatial learning and memory in diabetic rats. Materials and Methods: This experimental study was carried out on 5 groups of male Wistar rats (n=10 for each): the control animals (C)...
Background and Objective: Memory naturally degrades with the passing of time. Dementia or deficit of memory caused by Alzheimer’s disease, aging and other risk factors, greatly affects one’s day-to-day life. Lavandula officinalis is an effective medicinal plant in treating inflammation, epilepsy, depression and anxiety. Also, recently have been submitted reports about the effects of lavender on...
Brain-derived neurotrophic factor (BDNF) regulates both short-term synaptic functions and activity-dependent synaptic plasticity such as long-term potentiation. In the present study, we investigated the role of BDNF in the spatial reference and working memory in a radial arm maze test. The radial arm maze training resulted in a significant increase in the BDNF mRNA expression in the hippocampus...
Background and Purpose: Learning disorder is one of the common disorders in students, which can lead to the occurrence of educational problems and secondary disorders in them. Based on psychopathological criteria, dyscalculia is one of the subcategories of learning disorder. Children with this disorder have problems in perception of spatial relations and in different cognitive abilities. Theref...
Introduction: Crystal meth by induction of free radical formation in brains cells and lipid peroxidation cause to the apoptosis. The aim of present study is to investigate the effect of extract of Scrophularia striataon spatial memory, lipid peroxidation and alteration of antioxidant enzymes levels. Methods: In this experimental study, 42 male Wistar rats were divided into 6 groups, including:...
Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recover...
Exposure to environmental tobacco smoke (ETS) in the early postnatal period has been associated with several diseases; however, little is known about the brain effects of ETS exposure during this critical developmental period or the long-term consequences of this exposure. This study investigated the effects of the early postnatal ETS exposure on both reference and working memory, synaptic prot...
Recently it was shown that holeboard training can reinforce, i.e., transform early-LTP into late-LTP in the dentate gyrus during the initial formation of a long-term spatial reference memory in rats. The consolidation of LTP as well as of the reference memory was dependent on protein synthesis. We have now investigated the transmitter systems involved in this reinforcement and found that LTP-co...
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