Memory is the cognitive ability that allows acquiring, store and recalling information. Anterior thalamic dysfunction creates memory deficits in rats and humans. Anterior thalamus forms a memory network in connection with the hippocampus. This connectivity profile proposes that ventrolateral and anterior thalamus may display a nexus between reminder and control functions, such as action or atte...

Directed actions can play a causal role in cognition, shaping thought processes. What drives this cross-talk between action and thought? I investigated the hypothesis that representations in spatial working memory mediate interactions between directed actions and problem solving. Participants attempted to solve an insight problem while occasionally either moving their eyes in a pattern embodyin...

Spatial working memory deficits associated with dorsolateral prefrontal dysfunction have been found in Caucasian samples of schizophrenia patients and their first-degree relatives. This study evaluated spatial working memory function in affected and unaffected members of multiplex schizophrenia families from the Republic of Palau to determine whether the spatial working memory deficits associat...

Neuroimaging studies in humans have consistently found robust activation of frontal, parietal, and temporal regions during working memory tasks. Whether these activations represent functional networks segregated by perceptual domain is still at issue. Two functional magnetic resonance imaging experiments were conducted, both of which used multiple-cycle, alternating task designs. Experiment 1 c...

OBJECTIVE This study tested the hypothesis that impaired working memory is a core deficit underlying multiple neuropsychological deficits in schizophrenia patients. METHOD The subjects were 27 men with stable chronic schizophrenia treated with atypical antipsychotics and 38 normal participants. They were assessed with a battery of neuropsychological tests. Verbal working memory was measured w...

OBJECTIVES There is controversial evidence about the effect of methamphetamine (METH) on spatial memory. We tested the time- dependent effects of METH on spatial short-term (working) and long-term (reference) memory in METH -sensitized and withdrawn rats in the Morris water maze. MATERIALS AND METHODS Rats were sensitized to METH (2 mg/kg, daily/5 days, SC). Rats were trained in water maze (4...