Abstract Purpose The quantitative accuracy of Nuclear Medicine images, acquired for both planar and SPECT studies, is influenced by the isotope-collimator combination as well image corrections incorporated in iterative reconstruction process. These factors can be investigated optimised using Monte Carlo simulations. This study aimed to evaluate quantification 123 I with low-energy high resoluti...

The authors present a new method to compensate for the spatially variant detector response in single photon emission computed tomography (SPECT) with varying focal-length fan-beam (VFF) geometry. In this method, the deblurred projection is explicitly expressed as an integral of the collimator blurred data and the fully calibrated system kernel matrix with certain transforms. It needs a little m...

OBJECTIVES Although transgenic mice have emerged as powerful experimental models of cardiovascular disease, methods for in vivo phenotypic assessment and characterization remain limited, motivating the development of new instruments for biologic measurement. BACKGROUND We have developed a single-photon emission computed tomography system with a pinhole collimator (pinhole SPECT) for high-reso...

2 Cover illustration: The logarithm of a 123 I point spread function. The point source was simulated at 14.0 cm distance from the collimator in air, with the SIMIND version described in Paper V, using parameters corresponding to a GE Millennium MPR with 2.3 × 2.3 m 2 field of view. The grey scale is processed. To Björn, family and friends If you don't care where you are, you ain't lost. ABSTRAC...

UNLABELLED We determined the relative effect of corrections for scatter, depth-dependent collimator response, attenuation, and finite spatial resolution on various image characteristics in cardiac SPECT. METHODS Monte Carlo simulations and real acquisition of a 99mTc cardiac phantom were performed under comparable conditions. Simulated and acquired data were reconstructed using several correc...

OBJECTIVE To compare the diagnostic performance of a new dedicated ultrafast solid-state cardiac camera (Discovery NM 530c [DNM]) with standard dual detector cameras (S-SPECT) in myocardial perfusion imaging. The primary goal was a per-patient analysis of diagnostic performance of the DNM using S-SPECT as the reference standard. METHODS AND RESULTS In total, 168 patients underwent one-day Tc-...

Introduction: SPECT is a diagnostic imaging technique the main disadvantage of which is the existence of Poisson noise. So far, different methods have been used by scientists to improve SPECT images. The Wavelet Transform is a new method for de-noising which is widely used for noise reduction and quality enhancement of images. The purpose of this paper is evaluation of noise reduction in SPECT ...