Fluoroquinolones are broad-spectrum antibiotics that target gyrase and topoisomerase IV, involved in DNA compaction segregation. We synthesized 28 novel norfloxacin hydroxamic acid derivatives with additional metal-chelating hydrophobic pharmacophores,...

There is a critical need to better use existing antibiotics due to the urgent threat of antibiotic resistant bacteria coupled with the reduced effort in developing new antibiotics. β-lactam antibiotics represent one of the most commonly used classes of antibiotics to treat a broad spectrum of Gram-positive and -negative bacterial pathogens. However, the rise of extended spectrum β-lactamase (ES...

BACKGROUND Antibiotic resistance is a growing problem worldwide. Mechanisms of resistance vary, and some can confer resistance to multiple classes of antibiotics. OBJECTIVE To characterise the antibiotic resistance profiles of Escherichia coli isolates obtained from stool samples of young rural children exposed or unexposed to antibiotics. METHODOLOGY The samples were collected from childre...

The early eighties saw the introduction of a new group of antibiotics known as the carbapenems, which exhibited broader spectrum of activity as compared to cephalosporins. These group of antibiotics were active against Gram negative bacilli including non-fermenters like Pseudomonas producing extended spectrum betalactamases (ESBLs) and AmpC betalactamases (Deshpande et al., 2004; Gladstone et a...

Chryseobacterium indologenes is a rare cause of infection in infants. The majority of case reports belong to hospitalized infants with indwelling devices. We are presenting a rare case of Chryseobacterium indologenes meningitis in a healthy newborn with no neonatal intensive care unit admissions or indwelling devices. The pathogen is resistant to many antibiotics and the patient was successfull...

BACKGROUND Resistance to antibiotics is a major public-health problem and antibiotic use is being increasingly recognised as the main selective pressure driving this resistance. Our aim was to assess outpatient use of antibiotics and the association with resistance. METHODS We investigated outpatient antibiotic use in 26 countries in Europe that provided internationally comparable distributio...

OBJECTIVE To compare antibiotic prescribing in primary care in two European populations, one in Denmark (Funen), the other in Italy (Ravenna). METHODS Reimbursement data (1999) were retrieved from the Odense Pharmacoepidemiologic Database (Denmark) and the Emilia Romagna Health Authority Database (Italy). The extent of antibiotic use (ATC J01) was analysed as the number of defined daily doses...

conclusions all the bacterial isolates were associated with a high resistance to various antibiotics and this resistant pattern could be confirmed by detection of a particular gene for each bacterium. objectives this study examined bacteremia in cancer patients from two medical centers regarding isolates and spectrum of antibiotic resistance pattern. patients and methods this was a prospective ...

conclusions the β-lactamase disk test is appropriately sensitive to detect esbls in mdr isolates of e. coli. background most urinary tract infections (utis) are caused by escherichia coli (e. coli) species. due to infections outbreaks of e. coli strains with multiple mechanisms of resistance to β-lactam antibiotics, the sensitivity of confirmatory tests to detect the extended spectrum β-lactama...