background: active immunization against gnrh decreases the secretion of gonadotropins and causes cessation of gonadal function, thereby, inducing infertility. based on the immunoenhancing activity of kamdhenu ark (distilled cow urine), this study was performed to evaluate its effects on the gonadosomatic indices (gsi) and sperm parameters in male mice receiving a gnrh contraceptive vaccine. met...

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Recent studies show that spermatozoal DNA integrity is essential for normal fertilization and transmission of paternal genetic information to the offspring. Additionally, fertilization and embryo development depend on the sperm DNA structure (1,2). Generally, while fertile men have high levels of sperm with intact DNA...

oxidative stress is one of the important causes of the type 1 diabetes induced changes in the sperm quality. bioflavonoids, rutin 10 mg/kg and naringin 10 mg/kg were evaluated for their protective effects on sperm parameters, oxidative stress, and histopathology of type 1 diabetic rats. results demonstrated the reduction in sperm count, sperm motility and vitality in diabetic rats. mass drug ad...

Osmotic stress is an important factor that can result in cell damage during cryopreservation. Before ejaculation or collection for cryopreservation, murine spermatozoa are stored in epididymal fluid, a physiologically hyperosmotic environment (approximately 415 mmol/kg). The objectives of this study were to determine the osmotic tolerance limits of sperm motion parameters of ICR and C57BL/6 mou...

In humans, it is widely demonstrated that maternal obesity negatively affects fertility, pregnancy outcomes and offspring’s health. Less is known about the effects of paternal obesity on fertility and offspring’s development. Recent observations in animal models show that dietinduced obese males have impaired sperm quality, delayed preimplantation growth of the fertilized oocyte, and reduced im...

Background: Studies suggest that global semen quality is declining, but the debate remains open owing to geographic variation. Objectives: To evaluate temporal trends of sperm parameters – namely concentration, motility and total motile sperm count – in sperm donated during the period 1995–2009. methods: In a retrospective longitudinal cohort study we analyzed the sperm count and motility of 21...

Background: Vitamin E is believed to be the primary component of the antioxidant system in spermatozoa. There is a relationship between activity of these antioxidant and function of sperm. Vitamins E and C which are belong to non-enzymatic antioxidant are used as a supplemented drug to improve sperm quality and male fertility. The present study was carried out to investigate the positive effect...

Unexplained infertility requires that more sensitive and mechanism-based biomarkers should be developed and used independently of or in addition to conventional semen parameters for an infertility diagnosis. In the present study, semen samples were collected from young men participating in the Male Reproductive Health in Chongqing College students (MARCHS) cohort study in the follow-up stage in...

Background: Cigarette smoking is associated with impairment of testicular function. Nicotine is a major component of cigarette smoke.In the present study we aimed to study the effect of administration of nicotine-melatonin on sperm parameters in adult mouse. Materials and Methods: Male NMRI mice were divided into 4 groups: 1) control(normal saline) group 2) nicotine treated group 3) melatonin t...

BACKGROUND Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the risk factors of impaired male fertility potential. Studies have investigated the effect of CP/CPPS on several semen parameters but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the association between CP/CPPS and basic semen parameters in adult me...