Precipitation process in an A1-0.25 wt.%Sc alloy aged at 573 K has been investigated by resistivity and hardness measurements, transmission electron microscopy, and atom-probe field ion microscopy. It was found that the equilibrium A13Sc phase particles precipitate homogeneously from the begining. The particles coarsen following the Lifschitz-Wagner rule after the completion of the nucleation-a...

Nonsense-mediated mRNA decay (NMD) represents a highly conserved RNA surveillance mechanism through which mRNA transcripts bearing premature termination codons (PTCs) are selectively degraded to maintain transcriptomic fidelity in the cell. Numerous in vitro studies have demonstrated the importance of the NMD pathway; however, evidence supporting its physiological necessity has only just starte...

A new method for the extraction of the active coagulation component from Moringa oleifera seeds was developed and compared with the ordinary water extraction method (MOC-DW). In the new method, 1.0 mol l-1 solution of sodium chloride (MOC-SC) and other salts were used for extraction of the active coagulation component. Batch coagulation experiments were conducted using 500 ml of low turbid wate...

component type C plugs into architecture Figure 1. Concept of Abstract Component Specification Now, suppose that there are one or more concrete components K1...Kn that can potentially be used with A as a component that satisfies C, as shown in Figure 2. For this to be semantically viable, the specification of a Ki, SKi must be compatible with SC (i.e., SKi implies SC) and Ki must be a faithful ...

Nerve damage, a characteristic of leprosy, is the cause of patient deformities and a consequence of Schwann cells (SC) infection by Mycobacterium leprae. Although function/dysfunction of SC in human diseases like leprosy is difficult to study, many in vitro models, including SC lines derived from rat and/or human Schwannomas, have been employed. ST88-14 is one of the cell lineages used by many ...

Background: Pesticide application before transplanting crops has been widely used in rice as an economical and effective method for reducing the use of chemical pesticides. This study focused on feasibility pesticides a fresh corn nursery to control Spodoptera frugiperda. Methods: Three pesticides, including 35% Chlorantraniliprole WDG, 6% Spinetoram SC, 3% Emamectin Benzoate combined with Poly...

Nuclear mRNA transport is often thought of in terms of translocation through the nuclear pore, but mRNA export also requires intranuclear progression of transcripts from the gene to the nuclear pore. In some genetic diseases, failed export of a mutant mRNA is critical to the phenotype, yet typically it is not well understood how nuclear export is impeded or whether mutant mRNA accumulates at a ...

The mammalian 70K protein, a component of the U1 small nuclear ribonucleoprotein involved in pre-mRNA splicing, interacts with a number of proteins important for regulating constitutive and alternative splicing. Similar proteins that interact with the yeast homolog of the 70K protein, Snp1p, have yet to be identified. We used the two-hybrid system to find four U1-Snp1 associating (Usa) proteins...

Alternative splicing transitions have been identified recently as a conserved component of vertebrate heart remodeling during postnatal development. Here we report that the targeted deletion of Dicer, specifically in adult mouse myocardium, reveals the role of microRNAs (miRNAs) in regulating networks of postnatal splicing transitions and in maintaining adult splicing programs. We demonstrate a...

The transition from juvenile to adult life is accompanied by programmed remodeling in many tissues and organs, which is key for organisms to adapt to the demand of the environment. Here we report a novel regulated alternative splicing program that is crucial for postnatnal heart remodeling in the mouse. We identify the essential splicing factor ASF/SF2 as a key component of the program, regulat...