Spicamycin, a nucleoside antibiotic containing fatty acids with a variety of chain lengths (C12-C18), showed potent antitumor activity against human gastric cancer SC-9 and human breast cancer MX-1 in a xenograft model. We have made several semi-synthetic spicamycin analogues (SPMs) which differed in the chain length of the fatty acid moiety, and examined their structure-antitumor activity rela...

Presence of free air in the mediastinum without any identifiable cause is defined as spontaneous pneumomediastinum (SPM). SPM is more common in young males. The common inciting event leading to SPM are retching, vomiting, acute asthma attack, intense sport activity, inhalation of drugs and weight loss as seen in anorexia nervosa. Analgesics and rest is the mainstay of treatment. Recurrence of S...

The FIL Methods Group (and honorary members) This is SPM12 1 , a major update to the SPM software, containing substantial theoretical, algorithmic, structural and interface enhancements over previous versions, as detailed in this document. Although SPM12 will read image files from previous versions of SPM, there are differences in the algorithms, templates and models used. Therefore, we recomme...

Digital product passports (DPPs) may help bridge prevailing information gaps along value chains, and thus support actors’ sustainable management (SPM) decisions by providing needed life cycle data. However, different factors influence their successful adoption. This paper provides empirical insights into the perceived potential of DPP adoption in SPM. The focus was placed on DPPs for electric v...

We describe a self-organising pseudo-articulatory speech production model (SPM) trained on an X-ray microbeam database, and present results when using the SPM within a speech recognition framework. Given a time-aligned phonemic string, the system uses an explicit statistical model of co-articulation to generate pseudoarticulator trajectories. From these, parametrised speech vectors are synthesi...

Raven's Standard Progressive Matrices (SPM) has been suggested to assist in the detection of malingering, and a putatively validated formula method for defining genuine and fake performances is available In the present study, 47 normal individuals were asked to fake cognitive impairment on the SPM; a day later, their genuine performances were obtained. As expected, the genuine performances were...

Heterotrophic activities on sinking particulate matter (SPM) play an important role in SPM fluxes in the ocean. To demonstrate regional differences in heterotrophic activities on SPM, we measured heterotrophic bacterial production (HBP) in seawater (HBP(SW)) and SPM (HBP(SPM)) as well as potential extracellular enzyme activity (EEA) in SPM on a transect along 155°E in the western North Pacific ...

BACKGROUND Single-nucleotide polymorphisms in the promoter region of the FAS and FASLG may alter the transcriptional activity of these genes. We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN). METHODS We used log-rank test and Cox proportional hazard mo...

Phosphatidylserine (PtdSer) incubated with synaptosomal plasma membranes (SPM) of dog brain is incorporated into SPM in proportion to its concentration in the incubation medium. Low PtdSer concentrations progressively activated the SPM-associated (Na+ + K+)-stimulated ATPase and acetylcholinesterase. Increasing the PtdSer concentration above that which maximally stimulated the enzyme activities...

An approach for combined imaging of elastic and electromechanical properties of materials, referred to as piezoacoustic scanning probe microscopy PA-SPM , is presented. Applicability of this technique for elastic and electromechanical imaging with nanoscale resolution in such dissimilar materials as ferroelectrics and biological tissues is demonstrated. The PA-SPM signal formation is analyzed b...