The human DNA mismatch repair genes hMSH2 and hMLH1 are responsible for the development of hereditary nonpolyposis colorectal cancer (HNPCC). Although genetic alteration of the coding region of hMSH2 and hMLH1 has been well investigated in HNPCC patients, the regulatory regions of these genes have been poorly investigated, though recent studies have defined and characterized the core promoter r...

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is downregulated during the early stages of colorectal carcinogenesis. The aim of the present study was to investigate the potential role of 15-PGDH in normal-appearing colorectal mucosa as a biomarker for predicting colorectal neoplasms. We obtained paired tumor and normal tissues from the surgical specimens of 32 sporadic colorectal cancer patie...

background: colorectal cancer, the third most common type of cancer is a major cause of mortality worldwide. if colorectal cancer is detected at the early stages, the 5-year survival rate is 90%. meis1 homeobox gene is implicated in numerous solid tumors and hematological malignancies. therefore, the present study aims to investigate the methylation status of the meis1 gene in colorectal cancer...

Patients with ulcerative colitis and Crohn's disease are at increased risk for developing colorectal cancer. To date, no known genetic basis has been identified to explain colorectal cancer predisposition in these inflammatory bowel diseases. Instead, it is assumed that chronic inflammation is what causes cancer. This is supported by the fact that colon cancer risk increases with longer duratio...

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

background colorectal cancer (crc) is one of the most common cancers worldwide which is not extensively researched in iran. objectives the present study aims to investigate the epidemiologic characteristics of crc in patients referred to selected hospitals of tehran university of medical sciences. patients and methods in this descriptive-analytic study 218 patients with colorectal cancer were i...

Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran. Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 an...

During the course of screening the 5' half of exon 15 of the APC gene for germline and somatic mutations in two groups of patients, those with the inherited cancer prone syndrome adenomatous polyposis coli (APC) or with sporadic colorectal cancer, we have identified a number of intragenic changes that are not associated with the disease phenotype. Four of these changes are rare variants, each c...